DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment zetaTry and Prss12

DIOPT Version :9

Sequence 1:	NP_523691.1	Gene:	zetaTry / 36216	FlyBaseID:	FBgn0011556	Length:	280	Species:	Drosophila melanogaster
Sequence 2:	NP_032965.1	Gene:	Prss12 / 19142	MGIID:	1100881	Length:	761	Species:	Mus musculus

Alignment Length:	277	Identity:	87/277 - (31%)
Similarity:	125/277 - (45%)	Gaps:	46/277 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 GLPLLEDLDEKSVPDGRIVGGYATDIAQVPYQISLRYKGITTPENPFRHRCGGSIFNETTIVTAA 86
            ||.||....:      ||:||..:.....|:|.|||   :.:.....|..||.::.:...::|||
Mouse   506 GLRLLHRRQK------RIIGGNNSLRGAWPWQASLR---LRSAHGDGRLLCGATLLSSCWVLTAA 561

  Fly    87 HCV--IGTVASQYKVVAG-------TNFQTGSDGVITNVKEIVMHEGYYSGAAYNNDIAILFVDP 142
            ||.  .|..:..|.|..|       ..|:..     ..|::||:|..|....: :.|||::.:..
Mouse   562 HCFKRYGNNSRSYAVRVGDYHTLVPEEFEQE-----IGVQQIVIHRNYRPDRS-DYDIALVRLQG 620

  Fly   143 P----LPLNNFTIKA-IKLALEQPIEGTVSK--VSGWGTTSPGGYSSNQLLAVDVPIVSNELCDQ 200
            |    ..|:...:.| :.|..|:| :.|.|.  ::|||.|  |...|..|....||::....|.:
Mouse   621 PGEQCARLSTHVLPACLPLWRERP-QKTASNCHITGWGDT--GRAYSRTLQQAAVPLLPKRFCKE 682

  Fly   201 DYEDFGDETYRITSAMLCAGK-RGVGGADACQGDSGGPLAVR--DE---LYGVVSWGNSCALPNY 259
            .|:..      .|..|||||. :.....|:|||||||||...  ||   :|||.|||..|.:.:.
Mouse   683 RYKGL------FTGRMLCAGNLQEDNRVDSCQGDSGGPLMCEKPDESWVVYGVTSWGYGCGVKDT 741

  Fly   260 PGVYANVAYLRPWIDAV 276
            ||||..|....|||.:|
Mouse   742 PGVYTRVPAFVPWIKSV 758

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zetaTry	NP_523691.1	Tryp_SPc	38..273	CDD:214473	80/256 (31%)
zetaTry	NP_523691.1	Tryp_SPc	39..276	CDD:238113	81/258 (31%)
Prss12	NP_032965.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	25..87
		KR	83..159	CDD:214527
		SR	166..265	CDD:214555
		SRCR	171..265	CDD:278931
		SR	273..372	CDD:214555
		SRCR	278..371	CDD:278931
		SR	386..485	CDD:214555
		SRCR	396..485	CDD:278931
		Zymogen activation region	505..516		4/15 (27%)
		Tryp_SPc	516..755	CDD:214473	80/256 (31%)
		Tryp_SPc	517..758	CDD:238113	81/258 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910