DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment zetaTry and PRSS36

DIOPT Version :9

Sequence 1:	NP_523691.1	Gene:	zetaTry / 36216	FlyBaseID:	FBgn0011556	Length:	280	Species:	Drosophila melanogaster
Sequence 2:	NP_775773.2	Gene:	PRSS36 / 146547	HGNCID:	26906	Length:	855	Species:	Homo sapiens

Alignment Length:	287	Identity:	90/287 - (31%)
Similarity:	129/287 - (44%)	Gaps:	32/287 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 AFLVSLVALTQGLPLLEDLD-EKSVPDGRIVGGYATDIAQVPYQISLRYKGITTPENPFRHRCGG 74
            ||..|.::.||..|  |||| .:..|..|||||........|:|:||.:.|        .|.|||
Human    20 AFQDSALSPTQEEP--EDLDCGRPEPSARIVGGSNAQPGTWPWQVSLHHGG--------GHICGG 74

  Fly    75 SIFNETTIVTAAHCVI--GTV--ASQYKVVAGTNFQTGS-DGVITNVKEIVMHEGYYSGAAYNND 134
            |:...:.:::||||.:  ||:  |:::.|:.|.:.|.|. ||..|.....::....||......|
Human    75 SLIAPSWVLSAAHCFMTNGTLEPAAEWSVLLGVHSQDGPLDGAHTRAVAAIVVPANYSQVELGAD 139

  Fly   135 IAILFVDPPLPLNNFTIK-AIKLALEQPIEGTVSKVSGWGTTS-----PGGYSSNQLLAVDVPIV 193
            :|:|.:..|..|...... .:..|..:.:.||....:|||...     |..:   .|..|::.::
Human   140 LALLRLASPASLGPAVWPVCLPRASHRFVHGTACWATGWGDVQEADPLPLPW---VLQEVELRLL 201

  Fly   194 SNELCDQDYEDFG--DETYRITSAMLCAGKRGVGGADACQGDSGGPLAVRDE----LYGVVSWGN 252
            ....|...|...|  :.|.:|...||||| ...|..|.|||||||||...:.    ..|:.|:|.
Human   202 GEATCQCLYSQPGPFNLTLQILPGMLCAG-YPEGRRDTCQGDSGGPLVCEEGGRWFQAGITSFGF 265

  Fly   253 SCALPNYPGVYANVAYLRPWIDAVLAG 279
            .|...|.|||:..||....||...:.|
Human   266 GCGRRNRPGVFTAVATYEAWIREQVMG 292

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zetaTry	NP_523691.1	Tryp_SPc	38..273	CDD:214473	76/251 (30%)
zetaTry	NP_523691.1	Tryp_SPc	39..276	CDD:238113	77/253 (30%)
PRSS36	NP_775773.2	Tryp_SPc	46..286	CDD:214473	76/251 (30%)
		Tryp_SPc	47..289	CDD:238113	77/253 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	292..316		1/1 (100%)
		Tryp_SPc	330..538	CDD:304450
		Tryp_SPc	601..783	CDD:304450
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149417
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24276
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.030