DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment zetaTry and MASP2

DIOPT Version :9

Sequence 1:	NP_523691.1	Gene:	zetaTry / 36216	FlyBaseID:	FBgn0011556	Length:	280	Species:	Drosophila melanogaster
Sequence 2:	NP_006601.2	Gene:	MASP2 / 10747	HGNCID:	6902	Length:	686	Species:	Homo sapiens

Alignment Length:	285	Identity:	84/285 - (29%)
Similarity:	129/285 - (45%)	Gaps:	61/285 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 EKSVP-------------DGRIVGGYATDIAQVPYQISLRYKGITTPENPFRHRCGGSIFNETTI 82
            |||:|             .|||.||........|:|:.:  .|.||        ..|::..:..:
Human   424 EKSLPVCEPVCGLSARTTGGRIYGGQKAKPGDFPWQVLI--LGGTT--------AAGALLYDNWV 478

  Fly    83 VTAAHCV-------------IGTVASQYKVVAGTNFQTGSDGVITNVKEIVMHEGYYSGAAYNND 134
            :||||.|             :||:    |.::....|..|:.|.       :||||...|.::||
Human   479 LTAAHAVYEQKHDASALDIRMGTL----KRLSPHYTQAWSEAVF-------IHEGYTHDAGFDND 532

  Fly   135 IAILFVDPPLPLNNFTIKAIKLALEQPIE----GTVSKVSGWGTTSPGGYSSNQLLAVDVPIVSN 195
            ||::.::..:.:|: .|..|.|..::...    ..:...||||.|. .|:.:..|:.||:|||.:
Human   533 IALIKLNNKVVINS-NITPICLPRKEAESFMRTDDIGTASGWGLTQ-RGFLARNLMYVDIPIVDH 595

  Fly   196 ELCDQDYEDFGDETYRITSAMLCAGKRGVGGADACQGDSGGPLAVRDE------LYGVVSWGN-S 253
            :.|...||........:|:.|||||... ||.|:|:|||||.|...|.      :.|:||||: :
Human   596 QKCTAAYEKPPYPRGSVTANMLCAGLES-GGKDSCRGDSGGALVFLDSETERWFVGGIVSWGSMN 659

  Fly   254 CALPNYPGVYANVAYLRPWIDAVLA 278
            |......|||..|....|||:.:::
Human   660 CGEAGQYGVYTKVINYIPWIENIIS 684

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zetaTry	NP_523691.1	Tryp_SPc	38..273	CDD:214473	77/258 (30%)
zetaTry	NP_523691.1	Tryp_SPc	39..276	CDD:238113	78/260 (30%)
MASP2	NP_006601.2	CUB	28..134	CDD:214483
		EGF_CA	138..176	CDD:214542
		CUB	184..293	CDD:278839
		CCP	300..361	CDD:214478
		Sushi	366..430	CDD:278512	4/5 (80%)
		Tryp_SPc	444..679	CDD:214473	77/258 (30%)
		Tryp_SPc	445..682	CDD:238113	78/260 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910