DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment zetaTry and tmprss6

DIOPT Version :9

Sequence 1:	NP_523691.1	Gene:	zetaTry / 36216	FlyBaseID:	FBgn0011556	Length:	280	Species:	Drosophila melanogaster
Sequence 2:	XP_004913946.2	Gene:	tmprss6 / 100489045	XenbaseID:	XB-GENE-1011573	Length:	806	Species:	Xenopus tropicalis

Alignment Length:	282	Identity:	83/282 - (29%)
Similarity:	132/282 - (46%)	Gaps:	69/282 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 PDG---------------RIVGGYATDIAQVPYQISLRYKGITTPENPFRHRCGGSIFNETTIVT 84
            |||               |:|||......:.|:|.||:.:|        .|.|||::..:..|:|
Frog   552 PDGSDENNCGCGIQAVGIRLVGGTQAQEGEWPWQASLQVRG--------EHICGGTLVADQWILT 608

  Fly    85 AAHCV---------IGTV-ASQYKVVAGTNFQTGSDGVITNVKEIVMHEGYYSGAAYNNDIAILF 139
            ||||.         :.|| ..:.::...|..:     :...|..:|:|. :|...:::.|:|::.
Frog   609 AAHCFTPESYASPEVWTVYLGKVRLSRSTQKE-----LAFKVIRLVIHP-FYDEDSHDYDVALVL 667

  Fly   140 VDPPLPLNNFTIKAIKLALEQPI----------EGTVSKVSGWGTTSPGGYSSNQLLAVDVPIVS 194
            :|..:||.:..:        |||          .|:...|:|||:....|.:|:.|..||:.:|:
Frog   668 LDHLVPLTSPHV--------QPICLPSSTHHFPTGSSCWVTGWGSVKENGPTSDVLQKVDIQLVA 724

  Fly   195 NELCDQDYEDFGDETYRITSAMLCAGKRGVGGADACQGDSGGPLAVRDE-----LYGVVSWGNSC 254
            .::|.:.|.      |:|:..|||||.|. |..||||||||.||..:..     ..|:||||..|
Frog   725 QDICTELYR------YQISPRMLCAGYRD-GSKDACQGDSGSPLVCKTASGRWFQAGLVSWGAGC 782

  Fly   255 ALPNYPGVYANVAYLRPWIDAV 276
            .:|.|.|||:.:..|..||:::
Frog   783 GIPRYFGVYSRITRLVQWIESI 804

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zetaTry	NP_523691.1	Tryp_SPc	38..273	CDD:214473	78/259 (30%)
zetaTry	NP_523691.1	Tryp_SPc	39..276	CDD:238113	79/261 (30%)
tmprss6	XP_004913946.2	SEA	77..176	CDD:396113
		CUB	235..303	CDD:412131
		LDLa	448..478	CDD:238060
		LDLa	480..514	CDD:238060
		LDLa	525..560	CDD:238060	3/7 (43%)
		Tryp_SPc	572..804	CDD:238113	79/260 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910