DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kappaTry and Tmprss6

DIOPT Version :9

Sequence 1:	NP_610674.5	Gene:	kappaTry / 36215	FlyBaseID:	FBgn0043471	Length:	263	Species:	Drosophila melanogaster
Sequence 2:	NP_082178.2	Gene:	Tmprss6 / 71753	MGIID:	1919003	Length:	811	Species:	Mus musculus

Alignment Length:	252	Identity:	84/252 - (33%)
Similarity:	130/252 - (51%)	Gaps:	36/252 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 RIINGTTVDIARHPYLVSLRYRRDNESSYMHECAGVIISEQALITSAQCLYGLPEET----KLVA 85
            ||:.||.......|:..||:.|.      .|.|.|.:|:::.:||:|.|   ..|::    ||..
Mouse   576 RIVGGTVSSEGEWPWQASLQIRG------RHICGGALIADRWVITAAHC---FQEDSMASPKLWT 631

  Fly    86 VAGANTRNGT--DGFI-YPVANWTHHPNYDPVTVDNDIGVLLLDTTLDLTLLGISSIGIRPE-RP 146
            |.....|..:  .|.: :.|:....||.::..:.|.|:.:|.||..:      :.|..:||. .|
Mouse   632 VFLGKMRQNSRWPGEVSFKVSRLFLHPYHEEDSHDYDVALLQLDHPV------VYSATVRPVCLP 690

  Fly   147 A------VGRLATVAGWGYREEWGPSSYKLEQTEVPVVSSEQCTQIYGAGEVTERMICAGFVVQG 205
            |      .|:...:.|||.:.|.||.|..|::.:|.:|..:.|::.| ..:|:.||:|||: .:|
Mouse   691 ARSHFFEPGQHCWITGWGAQREGGPVSNTLQKVDVQLVPQDLCSEAY-RYQVSPRMLCAGY-RKG 753

  Fly   206 GSDACQGDTGGPLVI---DGQ--LVGLVSWGRGCARPNYPTVYCYVASFVDWIEETI 257
            ..||||||:|||||.   .|:  |.||||||.||.|||:..||..|...::||::.:
Mouse   754 KKDACQGDSGGPLVCREPSGRWFLAGLVSWGLGCGRPNFFGVYTRVTRVINWIQQVL 810

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kappaTry	NP_610674.5	Tryp_SPc	25..253	CDD:214473	82/246 (33%)
kappaTry	NP_610674.5	Tryp_SPc	26..256	CDD:238113	83/248 (33%)
Tmprss6	NP_082178.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..48
		SEA	88..185	CDD:279699
		LDLa	459..489	CDD:238060
		LDLa	495..525	CDD:238060
		Ldl_recept_a	529..566	CDD:278486
		Tryp_SPc	576..806	CDD:214473	82/246 (33%)
		Tryp_SPc	577..809	CDD:238113	83/248 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D433637at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920