DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kappaTry and TMPRSS6

DIOPT Version :9

Sequence 1:	NP_610674.5	Gene:	kappaTry / 36215	FlyBaseID:	FBgn0043471	Length:	263	Species:	Drosophila melanogaster
Sequence 2:	NP_001275929.1	Gene:	TMPRSS6 / 164656	HGNCID:	16517	Length:	824	Species:	Homo sapiens

Alignment Length:	278	Identity:	82/278 - (29%)
Similarity:	128/278 - (46%)	Gaps:	60/278 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 PEGRIINGTTVDIARHPYLVSLRYRRDNESSYMHECAGVIISEQALITSAQCLYGLPEETKLVAV 86
            |..||:.|........|:..||:.|.      .|.|.|.:|:::.:||:|.|.    :|..:.:.
Human   564 PSSRIVGGAVSSEGEWPWQASLQVRG------RHICGGALIADRWVITAAHCF----QEDSMAST 618

  Fly    87 A------GANTRNGT-DGFI-YPVANWTHHPNYDPVTVDNDIGVLLLDTTLDLTLLGISSIGIRP 143
            .      |...:|.. .|.: :.|:....||.::..:.|.|:.:|.||..:      :.|..:||
Human   619 VLWTVFLGKVWQNSRWPGEVSFKVSRLLLHPYHEEDSHDYDVALLQLDHPV------VRSAAVRP 677

  Fly   144 E-RPA------VGRLATVAGWGYREE-------------WG---------PSSYKLEQTEVPVVS 179
            . .||      .|....:.|||...|             |.         |.|..|::.:|.::.
Human   678 VCLPARSHFFEPGLHCWITGWGALREGALRADAVALFYGWRNQGSETCCCPISNALQKVDVQLIP 742

  Fly   180 SEQCTQIYGAGEVTERMICAGFVVQGGSDACQGDTGGPLV---IDGQ--LVGLVSWGRGCARPNY 239
            .:.|:::| ..:||.||:|||: .:|..||||||:|||||   :.|:  |.||||||.||.||||
Human   743 QDLCSEVY-RYQVTPRMLCAGY-RKGKKDACQGDSGGPLVCKALSGRWFLAGLVSWGLGCGRPNY 805

  Fly   240 PTVYCYVASFVDWIEETI 257
            ..||..:...:.||::.:
Human   806 FGVYTRITGVISWIQQVV 823

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kappaTry	NP_610674.5	Tryp_SPc	25..253	CDD:214473	79/269 (29%)
kappaTry	NP_610674.5	Tryp_SPc	26..256	CDD:238113	80/271 (30%)
TMPRSS6	NP_001275929.1	SEA	77..177	CDD:307516
		CUB	326..440	CDD:238001
		LDLa	450..480	CDD:238060
		LDLa	486..516	CDD:238060
		Ldl_recept_a	520..557	CDD:278486
		Tryp_SPc	568..822	CDD:238113	80/271 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D433637at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920