DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kappaTry and PRSS36

DIOPT Version :9

Sequence 1:	NP_610674.5	Gene:	kappaTry / 36215	FlyBaseID:	FBgn0043471	Length:	263	Species:	Drosophila melanogaster
Sequence 2:	NP_775773.2	Gene:	PRSS36 / 146547	HGNCID:	26906	Length:	855	Species:	Homo sapiens

Alignment Length:	325	Identity:	79/325 - (24%)
Similarity:	127/325 - (39%)	Gaps:	107/325 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MCIPLLLLAIG------FSSVISIS---------GQPE--GRIINGTTVDIARHPYLVSLRYRRD 48
            :.:||::|.|.      ..|.:|.:         |:||  .||:.|:.......|:.|||.:...
Human     5 LLLPLVMLVISPIPGAFQDSALSPTQEEPEDLDCGRPEPSARIVGGSNAQPGTWPWQVSLHHGGG 69

  Fly    49 NESSYMHECAGVIISEQALITSAQCLYGLPEETKLVAVAGANTRNGTDGFIYPVANWT-----HH 108
                  |.|.|.:|:...::::|.|..                   |:|.:.|.|.|:     |.
Human    70 ------HICGGSLIAPSWVLSAAHCFM-------------------TNGTLEPAAEWSVLLGVHS 109

  Fly   109 -------------------PNYDPVTVDNDIGVLLLDTTLDLTLLGISSIGIRPERPAV------ 148
                               .||..|.:..|:.:|.|.:.        :|:|     |||
Human   110 QDGPLDGAHTRAVAAIVVPANYSQVELGADLALLRLASP--------ASLG-----PAVWPVCLP 161

  Fly   149 --------GRLATVAGWGYREEWG--PSSYKLEQTEVPVVSSEQCTQIYGAG-------EVTERM 196
                    |......|||..:|..  |..:.|::.|:.::....|..:|...       ::...|
Human   162 RASHRFVHGTACWATGWGDVQEADPLPLPWVLQEVELRLLGEATCQCLYSQPGPFNLTLQILPGM 226

  Fly   197 ICAGFVVQGGSDACQGDTGGPLVID--GQ--LVGLVSWGRGCARPNYPTVYCYVASFVDWIEETI 257
            :|||: .:|..|.||||:|||||.:  |:  ..|:.|:|.||.|.|.|.|:..||::..||.|.:
Human   227 LCAGY-PEGRRDTCQGDSGGPLVCEEGGRWFQAGITSFGFGCGRRNRPGVFTAVATYEAWIREQV 290

Fly 258 257
Human 291 290

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kappaTry	NP_610674.5	Tryp_SPc	25..253	CDD:214473	67/278 (24%)
kappaTry	NP_610674.5	Tryp_SPc	26..256	CDD:238113	68/280 (24%)
PRSS36	NP_775773.2	Tryp_SPc	46..286	CDD:214473	67/278 (24%)
		Tryp_SPc	47..289	CDD:238113	68/280 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	292..316
		Tryp_SPc	330..538	CDD:304450
		Tryp_SPc	601..783	CDD:304450
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149402
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D433637at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24276
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.950