DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kappaTry and tmprss6

DIOPT Version :9

Sequence 1:	NP_610674.5	Gene:	kappaTry / 36215	FlyBaseID:	FBgn0043471	Length:	263	Species:	Drosophila melanogaster
Sequence 2:	XP_004913946.2	Gene:	tmprss6 / 100489045	XenbaseID:	XB-GENE-1011573	Length:	806	Species:	Xenopus tropicalis

Alignment Length:	268	Identity:	83/268 - (30%)
Similarity:	128/268 - (47%)	Gaps:	42/268 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 SISGQPEG---------------RIINGTTVDIARHPYLVSLRYRRDNESSYMHECAGVIISEQA 66
            ||:..|:|               |::.||.......|:..||:.|.:      |.|.|.::::|.
Frog   547 SIADCPDGSDENNCGCGIQAVGIRLVGGTQAQEGEWPWQASLQVRGE------HICGGTLVADQW 605

  Fly    67 LITSAQCL----YGLPEETKLVAVAGANTRNGTDGFIYPVANWTHHPNYDPVTVDNDIGVLLLDT 127
            ::|:|.|.    |..||...:.......:|:......:.|.....||.||..:.|.|:.::|||.
Frog   606 ILTAAHCFTPESYASPEVWTVYLGKVRLSRSTQKELAFKVIRLVIHPFYDEDSHDYDVALVLLDH 670

  Fly   128 TLDLTLLGISSIGIRPERPA------VGRLATVAGWGYREEWGPSSYKLEQTEVPVVSSEQCTQI 186
            .:.||...:..|.:    |:      .|....|.|||..:|.||:|..|::.::.:|:.:.||::
Frog   671 LVPLTSPHVQPICL----PSSTHHFPTGSSCWVTGWGSVKENGPTSDVLQKVDIQLVAQDICTEL 731

  Fly   187 YGAGEVTERMICAGFVVQGGSDACQGDTGGPLV---IDGQ--LVGLVSWGRGCARPNYPTVYCYV 246
            | ..:::.||:|||: ..|..||||||:|.|||   ..|:  ..||||||.||..|.|..||..:
Frog   732 Y-RYQISPRMLCAGY-RDGSKDACQGDSGSPLVCKTASGRWFQAGLVSWGAGCGIPRYFGVYSRI 794

  Fly   247 ASFVDWIE 254
            ...|.|||
Frog   795 TRLVQWIE 802

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kappaTry	NP_610674.5	Tryp_SPc	25..253	CDD:214473	76/242 (31%)
kappaTry	NP_610674.5	Tryp_SPc	26..256	CDD:238113	78/244 (32%)
tmprss6	XP_004913946.2	SEA	77..176	CDD:396113
		CUB	235..303	CDD:412131
		LDLa	448..478	CDD:238060
		LDLa	480..514	CDD:238060
		LDLa	525..560	CDD:238060	4/12 (33%)
		Tryp_SPc	572..804	CDD:238113	78/243 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D433637at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920