DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lambdaTry and tmprss4a

DIOPT Version :9

Sequence 1:	NP_610673.1	Gene:	lambdaTry / 36214	FlyBaseID:	FBgn0043470	Length:	272	Species:	Drosophila melanogaster
Sequence 2:	XP_005157547.1	Gene:	tmprss4a / 777630	ZFINID:	ZDB-GENE-061103-631	Length:	458	Species:	Danio rerio

Alignment Length:	260	Identity:	98/260 - (37%)
Similarity:	153/260 - (58%)	Gaps:	30/260 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VLGVGCSLADPIYRNEEVHIPKLDGRIVGGQDTNITQYPHQISMRYRGNHRCGGTIYRSNQIISA 74
            |:.:.||....:.||::        |||||:|.:|..:|.|:|::|.|.|.|||::...|.:::|
Zfish   206 VISLSCSADCGLSRNQD--------RIVGGKDADIANWPWQVSLQYSGQHTCGGSLVTPNWVVTA 262

  Fly    75 AHCVNTLSGPENL---TIVAGSSNIWFPTGPQQELEVREIIIHPKYRTLNNDYDAAILILDGDFE 136
            |||.|. .|.:.|   |:|:|.:  :..:.|..  .|:|||::..|:...:|:|..::.|.....
Zfish   263 AHCFNG-DGRKALSRWTVVSGIT--YLSSTPSS--YVKEIIVNSNYKPAESDFDITMIKLQSPIT 322

  Fly   137 FNDAVQPIELAKERPDH-----DTPVTVTGWGTTSE-GGTISDVLQEVSVNVVDNSNCKN--AYS 193
            .:::.:|:.|.   |.:     ...:.|||||..:| ||::|.:||:..:.|:|::.|.:  .|.
Zfish   323 LSESRRPVCLP---PQNLGLKGGDGLVVTGWGHMAEKGGSLSSMLQKAQIQVIDSAQCSSPTVYG 384

  Fly   194 IMLTSRMLCAGVNGGGKDACQGDSGGPLVY---NNTLLGIVSWGTGCAREKYPGVYCSVPDVLDW 255
            ..:|.||:||||..||.||||||||||||:   ...|:|:||||.||||..:||||.:|..:|||
Zfish   385 SSITPRMICAGVMAGGVDACQGDSGGPLVHLADRWVLVGVVSWGVGCARPGFPGVYTNVDQMLDW 449

Fly 256 255
Zfish 450 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lambdaTry	NP_610673.1	Tryp_SPc	35..255	CDD:214473	91/233 (39%)
lambdaTry	NP_610673.1	Tryp_SPc	36..259	CDD:238113	92/234 (39%)
tmprss4a	XP_005157547.1	LDLa	74..105	CDD:238060
		SRCR_2	121..218	CDD:295335	3/11 (27%)
		Tryp_SPc	223..449	CDD:214473	91/233 (39%)
		Tryp_SPc	224..449	CDD:238113	90/232 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	178	1.000	Domainoid score	I3517
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H80930
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.910