DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lambdaTry and C1S

DIOPT Version :9

Sequence 1:	NP_610673.1	Gene:	lambdaTry / 36214	FlyBaseID:	FBgn0043470	Length:	272	Species:	Drosophila melanogaster
Sequence 2:	NP_001725.1	Gene:	C1S / 716	HGNCID:	1247	Length:	688	Species:	Homo sapiens

Alignment Length:	259	Identity:	69/259 - (26%)
Similarity:	113/259 - (43%)	Gaps:	39/259 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 RIVGGQDTNITQYPHQISMRYRGNHRCGGTIYRSNQIISAAHCVNTLSGPENLTIVAGSSNIWFP 99
            ||:||.|.:|..:|.|:   :..|...||.:.....:::|||.|   .|....|:..||:::...
Human   437 RIIGGSDADIKNFPWQV---FFDNPWAGGALINEYWVLTAAHVV---EGNREPTMYVGSTSVQTS 495

  Fly   100 -TGPQQELEVREIIIHPKYRTL-------NNDYDAAILILDGDFEFNDAVQPIELAKERPDHDTP 156
             ....:.|....:.|||.::.|       |.|.|.|::.|....:....|.||.|.....|::..
Human   496 RLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLM 560

  Fly   157 ----VTVTGWGTTSEGGTISDVLQEVSVNVVDNSNCK---------NAYSIMLTSRMLCAGVNGG 208
                ..::|||.| |....:..|:...:.|.....||         :|.:.:.|..|:||| ...
Human   561 DGDLGLISGWGRT-EKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAG-GEK 623

  Fly   209 GKDACQGDSGGPLVYNNT-------LLGIVSWGTGCAREKYPGVYCSVPDVLDWLVETVADKES 265
            |.|:|:|||||.....:.       ..|:||||..|...   |:|..|.:.:||:::|:.:..:
Human   624 GMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTY---GLYTRVKNYVDWIMKTMQENST 684

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lambdaTry	NP_610673.1	Tryp_SPc	35..255	CDD:214473	66/247 (27%)
lambdaTry	NP_610673.1	Tryp_SPc	36..259	CDD:238113	67/250 (27%)
C1S	NP_001725.1	CUB	18..129	CDD:238001
		FXa_inhibition	143..171	CDD:405372
		CUB	175..287	CDD:395345
		CCP	294..355	CDD:153056
		Sushi	359..421	CDD:395037
		Tryp_SPc	438..678	CDD:238113	67/250 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910