DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lambdaTry and C1R

DIOPT Version :9

Sequence 1:	NP_610673.1	Gene:	lambdaTry / 36214	FlyBaseID:	FBgn0043470	Length:	272	Species:	Drosophila melanogaster
Sequence 2:	NP_001341275.1	Gene:	C1R / 715	HGNCID:	1246	Length:	719	Species:	Homo sapiens

Alignment Length:	302	Identity:	88/302 - (29%)
Similarity:	131/302 - (43%)	Gaps:	70/302 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 GVGCSLADPIYRNEE--VHIPKL-------------DGRIVGGQDTNITQYPHQISMRYRGNHRC 61
            ||....|..|::||:  ..||:.             ..||:|||...:..:|.|:.....|  |.
Human   439 GVYTCTAQGIWKNEQKGEKIPRCLPVCGKPVNPVEQRQRIIGGQKAKMGNFPWQVFTNIHG--RG 501

  Fly    62 GGTIYRSNQIISAAHCVNTLSGPE-------NLTIVAGSSNIWFPTGPQQEL------EVREIII 113
            ||.:.....|::|||   ||...|       :|.:..|.:|:       :||      .:|.:.:
Human   502 GGALLGDRWILTAAH---TLYPKEHEAQSNASLDVFLGHTNV-------EELMKLGNHPIRRVSV 556

  Fly   114 HPKYR---TLNNDYDAAILILDGDFEFNDAVQPIELAKERPDHDTPVT------VTGWGTTSEGG 169
            ||.||   :.|.:.|.|:|.|:........:.||.|    ||:||...      |:|:|...|
Human   557 HPDYRQDESYNFEGDIALLELENSVTLGPNLLPICL----PDNDTFYDLGLMGYVSGFGVMEE-- 615

  Fly   170 TISDVLQEVSVNVVDNSNC------KNAYSIMLTSRMLCAGVNGGGKDACQGDSGGPLVYN--NT 226
            .|:..|:.|.:.|.:...|      ||...: .:..|.|||.....:|||||||||.....  ||
Human   616 KIAHDLRFVRLPVANPQACENWLRGKNRMDV-FSQNMFCAGHPSLKQDACQGDSGGVFAVRDPNT 679

  Fly   227 ----LLGIVSWGTGCAREKYPGVYCSVPDVLDWLVETVADKE 264
                ..||||||.||:|..  |.|..|.:.:||:.:.:.:::
Human   680 DRWVATGIVSWGIGCSRGY--GFYTKVLNYVDWIKKEMEEED 719

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lambdaTry	NP_610673.1	Tryp_SPc	35..255	CDD:214473	78/253 (31%)
lambdaTry	NP_610673.1	Tryp_SPc	36..259	CDD:238113	79/256 (31%)
C1R	NP_001341275.1	CUB	41..152	CDD:214483
		FXa_inhibition	175..203	CDD:317114
		CUB	207..316	CDD:278839
		Sushi	323..385	CDD:306569
		Sushi	390..461	CDD:306569	8/21 (38%)
		Tryp_SPc	477..711	CDD:214473	79/254 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910