DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lambdaTry and TMPRSS2

DIOPT Version :9

Sequence 1:	NP_610673.1	Gene:	lambdaTry / 36214	FlyBaseID:	FBgn0043470	Length:	272	Species:	Drosophila melanogaster
Sequence 2:	NP_001128571.1	Gene:	TMPRSS2 / 7113	HGNCID:	11876	Length:	529	Species:	Homo sapiens

Alignment Length:	236	Identity:	88/236 - (37%)
Similarity:	127/236 - (53%)	Gaps:	20/236 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 RIVGGQDTNITQYPHQISMRYRGNHRCGGTIYRSNQIISAAHCV-NTLSGPENLTIVAG---SSN 95
            |||||:......:|.|:|:..:..|.|||:|.....|::||||| ..|:.|.:.|..||   .|.
Human   292 RIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAGILRQSF 356

  Fly    96 IWFPTGPQQELEVREIIIHPKYRTLNNDYDAAILILDGDFEFNDAVQPIELAKE----RPDHDTP 156
            :::..|.|    |.::|.||.|.:...:.|.|::.|.....|||.|:|:.|...    :|:.  .
Human   357 MFYGAGYQ----VEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQ--L 415

  Fly   157 VTVTGWGTTSEGGTISDVLQEVSVNVVDNSNCKN--AYSIMLTSRMLCAGVNGGGKDACQGDSGG 219
            ..::|||.|.|.|..|:||....|.:::...|.:  .|..::|..|:|||...|..|:|||||||
Human   416 CWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGG 480

  Fly   220 PLV--YNNT--LLGIVSWGTGCAREKYPGVYCSVPDVLDWL 256
            |||  .||.  |:|..|||:|||:...||||.:|....||:
Human   481 PLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWI 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lambdaTry	NP_610673.1	Tryp_SPc	35..255	CDD:214473	86/233 (37%)
lambdaTry	NP_610673.1	Tryp_SPc	36..259	CDD:238113	87/235 (37%)
TMPRSS2	NP_001128571.1	DUF3824	<44..91	CDD:289625
		LDLa	150..185	CDD:238060
		SRCR_2	190..283	CDD:292133
		Tryp_SPc	292..521	CDD:214473	87/234 (37%)
		Tryp_SPc	293..524	CDD:238113	87/235 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100031
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810