DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lambdaTry and TMPRSS3

DIOPT Version :9

Sequence 1:	NP_610673.1	Gene:	lambdaTry / 36214	FlyBaseID:	FBgn0043470	Length:	272	Species:	Drosophila melanogaster
Sequence 2:	NP_076927.1	Gene:	TMPRSS3 / 64699	HGNCID:	11877	Length:	454	Species:	Homo sapiens

Alignment Length:	234	Identity:	91/234 - (38%)
Similarity:	129/234 - (55%)	Gaps:	13/234 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 RIVGGQDTNITQYPHQISMRYRGNHRCGGTIYRSNQIISAAHCVNTLSGPENLTIVAGSSNIWFP 99
            |||||..:.::|:|.|.|::::|.|.|||::.....||:|||||..|..|::.||..|..::...
Human   216 RIVGGNMSLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCVYDLYLPKSWTIQVGLVSLLDN 280

  Fly   100 TGPQQELEVREIIIHPKYRTLNNDYDAAILILDGDFEFNDAVQPIELAKER---PDHDTPVTVTG 161
            ..|...:|  :|:.|.||:......|.|::.|.|...||:.:||:.|....   ||.....| :|
Human   281 PAPSHLVE--KIVYHSKYKPKRLGNDIALMKLAGPLTFNEMIQPVCLPNSEENFPDGKVCWT-SG 342

  Fly   162 WGTTSEG-GTISDVLQEVSVNVVDNSNC--KNAYSIMLTSRMLCAGVNGGGKDACQGDSGGPLVY 223
            ||.|.:| |..|.||...:|.::.|..|  ::.|..:::..|||||...||.|:||||||||||.
Human   343 WGATEDGAGDASPVLNHAAVPLISNKICNHRDVYGGIISPSMLCAGYLTGGVDSCQGDSGGPLVC 407

  Fly   224 NN----TLLGIVSWGTGCAREKYPGVYCSVPDVLDWLVE 258
            ..    .|:|..|:|.|||....||||..|...|||:.|
Human   408 QERRLWKLVGATSFGIGCAEVNKPGVYTRVTSFLDWIHE 446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lambdaTry	NP_610673.1	Tryp_SPc	35..255	CDD:214473	88/229 (38%)
lambdaTry	NP_610673.1	Tryp_SPc	36..259	CDD:238113	90/233 (39%)
TMPRSS3	NP_076927.1	LDLa	74..107	CDD:238060
		SRCR_2	112..210	CDD:292133
		Tryp_SPc	216..444	CDD:214473	89/230 (39%)
		Tryp_SPc	217..447	CDD:238113	90/233 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100031
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810