DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lambdaTry and TMPRSS4

DIOPT Version :9

Sequence 1:	NP_610673.1	Gene:	lambdaTry / 36214	FlyBaseID:	FBgn0043470	Length:	272	Species:	Drosophila melanogaster
Sequence 2:	XP_005271670.1	Gene:	TMPRSS4 / 56649	HGNCID:	11878	Length:	494	Species:	Homo sapiens

Alignment Length:	279	Identity:	100/279 - (35%)
Similarity:	146/279 - (52%)	Gaps:	42/279 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSRILVVFLVLGVGCSLADPIYRNEEVHIPKLDGRIVGGQDTNITQYPHQISMRYRGNHRCGGTI 65
            :|..||....|..|.||..|              |:||.::.::..:|.|:|::|...|.|||:|
Human   184 LSGSLVSLHCLACGKSLKTP--------------RVVGVEEASVDSWPWQVSIQYDKQHVCGGSI 234

  Fly    66 YRSNQIISAAHCVNTLSGPENLTIVAGSSNIW-FPTGPQQELEVREIII---HPKYRTLNNDYDA 126
            ...:.:::||||....:...|..:.|||..:. ||:     |.|.:|||   :|.|   ..|.|.
Human   235 LDPHWVLTAAHCFRKHTDVFNWKVRAGSDKLGSFPS-----LAVAKIIIIEFNPMY---PKDNDI 291

  Fly   127 AILILDGDFEFNDAVQPIELAKERPDHD------TPVTVTGWGTTSE-GGTISDVLQEVSVNVVD 184
            |::.|.....|:..|:||.|    |..|      ||:.:.|||.|.: ||.:||:|.:.||.|:|
Human   292 ALMKLQFPLTFSGTVRPICL----PFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVID 352

  Fly   185 NSNCK--NAYSIMLTSRMLCAGVNGGGKDACQGDSGGPLVYNNT---LLGIVSWGTGCAREKYPG 244
            ::.|.  :||...:|.:|:|||:..||.|.|||||||||:|.:.   ::||||||.||.....||
Human   353 STRCNADDAYQGEVTEKMMCAGIPEGGVDTCQGDSGGPLMYQSDQWHVVGIVSWGYGCGGPSTPG 417

  Fly   245 VYCSVPDVLDWLVETVADK 263
            ||..|...|:|:.....|:
Human   418 VYTKVSAYLNWIYNVWKDR 436

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lambdaTry	NP_610673.1	Tryp_SPc	35..255	CDD:214473	90/235 (38%)
lambdaTry	NP_610673.1	Tryp_SPc	36..259	CDD:238113	90/238 (38%)
TMPRSS4	XP_005271670.1	LDLa	58..92	CDD:238060
		SRCR_2	108..197	CDD:295335	4/12 (33%)
		Tryp_SPc	204..429	CDD:214473	90/236 (38%)
		Tryp_SPc	205..432	CDD:238113	90/238 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H80930
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910