DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lambdaTry and TMPRSS15

DIOPT Version :9

Sequence 1:	NP_610673.1	Gene:	lambdaTry / 36214	FlyBaseID:	FBgn0043470	Length:	272	Species:	Drosophila melanogaster
Sequence 2:	XP_011527956.1	Gene:	TMPRSS15 / 5651	HGNCID:	9490	Length:	1064	Species:	Homo sapiens

Alignment Length:	239	Identity:	86/239 - (35%)
Similarity:	124/239 - (51%)	Gaps:	25/239 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 RIVGGQDTNITQYPHQISMRYRGNHRCGGTIYRSNQIISAAHCV--NTLSGPENLTIVAG---SS 94
            :||||.:.....:|..:.:.|.|...||.::..|:.::||||||  ..|. |...|.:.|   .|
Human   829 KIVGGSNAKEGAWPWVVGLYYGGRLLCGASLVSSDWLVSAAHCVYGRNLE-PSKWTAILGLHMKS 892

  Fly    95 NIWFPTGPQQELE-VREIIIHPKYRTLNNDYDAAILILDGDFEFNDAVQPIELAKER----PDHD 154
            |:   |.||.... :.||:|:|.|.....|.|.|::.|:....:.|.:|||.|.:|.    |..:
Human   893 NL---TSPQTVPRLIDEIVINPHYNRRRKDNDIAMMHLEFKVNYTDYIQPICLPEENQVFPPGRN 954

  Fly   155 TPVTVTGWGTTSEGGTISDVLQEVSVNVVDNSNCKN---AYSIMLTSRMLCAGVNGGGKDACQGD 216
              .::.||||....||.:::|||..|.::.|..|:.   .|:|  |..|:|||...||.|:||||
Human   955 --CSIAGWGTVVYQGTTANILQEADVPLLSNERCQQQMPEYNI--TENMICAGYEEGGIDSCQGD 1015

  Fly   217 SGGPLV--YNNT--LLGIVSWGTGCAREKYPGVYCSVPDVLDWL 256
            |||||:  .||.  |.|:.|:|..||....||||..|....:|:
Human  1016 SGGPLMCQENNRWFLAGVTSFGYKCALPNRPGVYARVSRFTEWI 1059

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lambdaTry	NP_610673.1	Tryp_SPc	35..255	CDD:214473	85/236 (36%)
lambdaTry	NP_610673.1	Tryp_SPc	36..259	CDD:238113	86/238 (36%)
TMPRSS15	XP_011527956.1	SEA	53..195	CDD:214554
		LDLa	229..263	CDD:238060
		CUB	270..376	CDD:278839
		MAM	387..547	CDD:214533
		MAM	392..547	CDD:99706
		CUB	569..676	CDD:278839
		LDLa	688..722	CDD:238060
		SR	723..816	CDD:214555
		Tryp_SPc	829..1059	CDD:214473	85/237 (36%)
		Tryp_SPc	830..1061	CDD:238113	86/238 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100031
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810