DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lambdaTry and MASP1

DIOPT Version :9

Sequence 1:	NP_610673.1	Gene:	lambdaTry / 36214	FlyBaseID:	FBgn0043470	Length:	272	Species:	Drosophila melanogaster
Sequence 2:	XP_011511291.1	Gene:	MASP1 / 5648	HGNCID:	6901	Length:	735	Species:	Homo sapiens

Alignment Length:	280	Identity:	80/280 - (28%)
Similarity:	127/280 - (45%)	Gaps:	43/280 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 IPKLDGRIVGGQDTNITQYPHQISMRYRGNHRC-------GGTIYRSNQIISAAHCVNTLS---- 82
            :|.|..||:||::.....:|.|..:......|.       .|.:..::.|::|||.:.:..
Human   450 LPSLVKRIIGGRNAEPGLFPWQALIVVEDTSRVPNDKWFGSGALLSASWILTAAHVLRSQRRDTT 514

  Fly    83 ----GPENLTIVAGSSNIWFPTGPQQELEVREIIIHPKYRTLNNDYDAAILILDGDFEFNDAVQP 143
                ..|::|:..|..::...:|.......| :::||.:...|.::|.|::.|.........|.|
Human   515 VIPVSKEHVTVYLGLHDVRDKSGAVNSSAAR-VVLHPDFNIQNYNHDIALVQLQEPVPLGPHVMP 578

  Fly   144 IELAKERPDHDTP---VTVTGWGTT----------SEG-GTISDVLQEVSVNVVDNSNCKNAY-- 192
            :.|.:..|:...|   ..|.|||.:          |.| .|:|||||.|.:.||.::.||.:|
Human   579 VCLPRLEPEGPAPHMLGLVAGWGISNPNVTVDEIISSGTRTLSDVLQYVKLPVVPHAECKTSYES 643

  Fly   193 ---SIMLTSRMLCAGVNGGGKDACQGDSGGPLVYNNTL------LGIVSWG--TGCAREKYPGVY 246
               :..:|..|.|||...||||.|.|||||..|..:.|      .|:||||  ..|..::..|||
Human   644 RSGNYSVTENMFCAGYYEGGKDTCLGDSGGAFVIFDDLSQRWVVQGLVSWGGPEECGSKQVYGVY 708

  Fly   247 CSVPDVLDWLVETVADKESV 266
            ..|.:.:||:.|.:...:||
Human   709 TKVSNYVDWVWEQMGLPQSV 728

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lambdaTry	NP_610673.1	Tryp_SPc	35..255	CDD:214473	73/261 (28%)
lambdaTry	NP_610673.1	Tryp_SPc	36..259	CDD:238113	74/264 (28%)
MASP1	XP_011511291.1	CUB	35..144	CDD:238001
		FXa_inhibition	160..188	CDD:291342
		CUB	192..301	CDD:278839
		Sushi	308..369	CDD:278512
		CCP	374..439	CDD:153056
		Tryp_SPc	456..718	CDD:214473	74/262 (28%)
		Tryp_SPc	457..718	CDD:238113	73/261 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910