DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lambdaTry and PRSS1

DIOPT Version :9

Sequence 1:	NP_610673.1	Gene:	lambdaTry / 36214	FlyBaseID:	FBgn0043470	Length:	272	Species:	Drosophila melanogaster
Sequence 2:	XP_011514713.1	Gene:	PRSS1 / 5644	HGNCID:	9475	Length:	472	Species:	Homo sapiens

Alignment Length:	232	Identity:	87/232 - (37%)
Similarity:	123/232 - (53%)	Gaps:	11/232 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 DGRIVGGQDTNITQYPHQISMRYRGNHRCGGTIYRSNQIISAAHCVNTLSGPENLTIVAGSSNIW 97
            |.:||||.:......|:|:|:. .|.|.|||::.....::||.||..:     .:.:..|..||.
Human   246 DDKIVGGYNCEENSVPYQVSLN-SGYHFCGGSLINEQWVVSAGHCYKS-----RIQVRLGEHNIE 304

  Fly    98 FPTGPQQELEVREIIIHPKY--RTLNNDYDAAILILDGDFEFNDAVQPIELAKERPDHDTPVTVT 160
            ...|.:|.:...:||.||:|  :||||  |..::.|......|..|..|.|....|...|...::
Human   305 VLEGNEQFINAAKIIRHPQYDRKTLNN--DIMLIKLSSRAVINARVSTISLPTAPPATGTKCLIS 367

  Fly   161 GWG-TTSEGGTISDVLQEVSVNVVDNSNCKNAYSIMLTSRMLCAGVNGGGKDACQGDSGGPLVYN 224
            ||| |.|.|....|.||.:...|:..:.|:.:|...:||.|.|.|...||||:||||||||:|.|
Human   368 GWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKITSNMFCVGFLEGGKDSCQGDSGGPVVCN 432

  Fly   225 NTLLGIVSWGTGCAREKYPGVYCSVPDVLDWLVETVA 261
            ..|.|:||||.|||::..||||..|.:.:.|:..|:|
Human   433 GQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIKNTIA 469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lambdaTry	NP_610673.1	Tryp_SPc	35..255	CDD:214473	83/222 (37%)
lambdaTry	NP_610673.1	Tryp_SPc	36..259	CDD:238113	84/225 (37%)
PRSS1	XP_011514713.1	Ig	19..119	CDD:299845
		IG_like	29..113	CDD:214653
		Tryp_SPc	248..464	CDD:214473	83/223 (37%)
		Tryp_SPc	249..467	CDD:238113	84/225 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BBP0
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D469244at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm42242
orthoMCL	1	0.900	-	-		OOG6_100031
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.720