DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lambdaTry and tmprss2

DIOPT Version :9

Sequence 1:	NP_610673.1	Gene:	lambdaTry / 36214	FlyBaseID:	FBgn0043470	Length:	272	Species:	Drosophila melanogaster
Sequence 2:	NP_001008623.1	Gene:	tmprss2 / 494080	ZFINID:	ZDB-GENE-041212-48	Length:	486	Species:	Danio rerio

Alignment Length:	245	Identity:	92/245 - (37%)
Similarity:	128/245 - (52%)	Gaps:	35/245 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 RIVGGQDTNITQ---YPHQISMRYRGNHRCGGTIYRSNQIISAAHCVNTLSGPENLTIVAGSSNI 96
            |||||  |.:|.   :|.|:|:.|.|.|.|||:|.....|::|||||:..|.|...|:.||...
Zfish   251 RIVGG--TTVTSKGVWPWQVSLHYSGRHLCGGSIITPYWILTAAHCVHQFSNPGGWTVYAGYLT- 312

  Fly    97 WFPTGPQQEL------EVREIIIHPKYRTLNNDYDAAILILDGDFEFNDAVQPIELAKERPDHDT 155
                  |.|:      .|..|:|| .:....|:.|.|::.|:.....:..::|:.|    |:...
Zfish   313 ------QSEMASASGNSVNRIVIH-DFNPNTNENDIALMRLNTALTISTNIRPVCL----PNKGM 366

  Fly   156 PVT------VTGWGTTSEGGTISDVLQEVSVNVVDNSNCKN--AYSIMLTSRMLCAGVNGGGKDA 212
            ..|      |||||....||:.|..|||..:.::|::.|.:  .|:.::|..|:|||...||.|:
Zfish   367 SFTAQQDCYVTGWGALFSGGSSSATLQEAKIQLIDSTICNSRPVYNGLITDTMICAGKLAGGVDS 431

  Fly   213 CQGDSGGPLVYNNT----LLGIVSWGTGCAREKYPGVYCSVPDVLDWLVE 258
            ||||||||||.|..    |||..|||.|||....||||.:|...|||:.:
Zfish   432 CQGDSGGPLVTNVRSLWWLLGDTSWGDGCAVRNKPGVYGNVTYFLDWIYQ 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lambdaTry	NP_610673.1	Tryp_SPc	35..255	CDD:214473	90/240 (38%)
lambdaTry	NP_610673.1	Tryp_SPc	36..259	CDD:238113	91/244 (37%)
tmprss2	NP_001008623.1	LDLa	132..168	CDD:238060
		SRCR_2	173..248	CDD:295335
		Tryp_SPc	251..479	CDD:214473	91/241 (38%)
		Tryp_SPc	252..482	CDD:238113	91/244 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100031
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810