DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lambdaTry and ACR

DIOPT Version :9

Sequence 1:	NP_610673.1	Gene:	lambdaTry / 36214	FlyBaseID:	FBgn0043470	Length:	272	Species:	Drosophila melanogaster
Sequence 2:	NP_001088.2	Gene:	ACR / 49	HGNCID:	126	Length:	421	Species:	Homo sapiens

Alignment Length:	288	Identity:	84/288 - (29%)
Similarity:	128/288 - (44%)	Gaps:	41/288 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VFLVLGVG------------CSLADPIYRNEEVHIPKLDGRIVGGQDTNITQYPHQISMR---YR 56
            :.|||.|.            |.|.   :|..    |:...|||||:......:|..:|::   |.
Human     9 ILLVLAVSVVAKDNATCDGPCGLR---FRQN----PQGGVRIVGGKAAQHGAWPWMVSLQIFTYN 66

  Fly    57 GN--HRCGGTIYRSNQIISAAHCVNTLSGPENLTIVAGSSNIWFPT-----GPQQELEVREIIIH 114
            .:  |.|||::..|..:::||||....:...:..:|.|:..|.:..     .|.||..|.:||||
Human    67 SHRYHTCGGSLLNSRWVLTAAHCFVGKNNVHDWRLVFGAKEITYGNNKPVKAPLQERYVEKIIIH 131

  Fly   115 PKYRTLNNDYDAAILILDGDFEFNDAVQPIELAKER---PDHDTPVTVTGWGTTSE-GGTISDVL 175
            .||.:.....|.|::.:.........:.|..|...:   |.......|.|||...| ....|.:|
Human   132 EKYNSATEGNDIALVEITPPISCGRFIGPGCLPHFKAGLPRGSQSCWVAGWGYIEEKAPRPSSIL 196

  Fly   176 QEVSVNVVDNSNCKNA--YSIMLTSRMLCAGVNGGGKDACQGDSGGPLVYNNT------LLGIVS 232
            .|..|:::|...|.:.  |:..:....:|||...|..|.|||||||||:..::      ::||.|
Human   197 MEARVDLIDLDLCNSTQWYNGRVQPTNVCAGYPVGKIDTCQGDSGGPLMCKDSKESAYVVVGITS 261

  Fly   233 WGTGCAREKYPGVYCSVPDVLDWLVETV 260
            ||.||||.|.||:|.:....|:|:...:
Human   262 WGVGCARAKRPGIYTATWPYLNWIASKI 289

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lambdaTry	NP_610673.1	Tryp_SPc	35..255	CDD:214473	75/241 (31%)
lambdaTry	NP_610673.1	Tryp_SPc	36..259	CDD:238113	75/244 (31%)
ACR	NP_001088.2	Tryp_SPc	42..285	CDD:214473	75/242 (31%)
		Tryp_SPc	43..288	CDD:238113	75/244 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	297..316
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	327..383
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	397..421
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910