DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lambdaTry and TMPRSS11F

DIOPT Version :9

Sequence 1:	NP_610673.1	Gene:	lambdaTry / 36214	FlyBaseID:	FBgn0043470	Length:	272	Species:	Drosophila melanogaster
Sequence 2:	NP_997290.2	Gene:	TMPRSS11F / 389208	HGNCID:	29994	Length:	438	Species:	Homo sapiens

Alignment Length:	236	Identity:	86/236 - (36%)
Similarity:	127/236 - (53%)	Gaps:	22/236 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 RIVGGQDTNIT-QYPHQISMRYRGN-HRCGGTIYRSNQIISAAHCVNTLSGPENLTIVAGSSNIW 97
            |||.|::|.:. ::|.|.|::..|: |:||.::..:..:::||||......|.......|::
Human   205 RIVQGRETAMEGEWPWQASLQLIGSGHQCGASLISNTWLLTAAHCFWKNKDPTQWIATFGAT--- 266

  Fly    98 FPTGPQQELEVREIIIHPKYRTLNNDYDAAILILDGDFEFNDAVQPIELAKERPDHD------TP 156
             .|.|..:..||:||:|..|....|:.|.|::.|....||::.||.:.|    ||..      |.
Human   267 -ITPPAVKRNVRKIILHENYHRETNENDIALVQLSTGVEFSNIVQRVCL----PDSSIKLPPKTS 326

  Fly   157 VTVTGWGTTSEGGTISDVLQEVSVNVVDNSNC--KNAYSIMLTSRMLCAGVNGGGKDACQGDSGG 219
            |.|||:|:..:.|.|.:.|::..|..:....|  |:.|..::|..|||||...|..|||:|||||
Human   327 VFVTGFGSIVDDGPIQNTLRQARVETISTDVCNRKDVYDGLITPGMLCAGFMEGKIDACKGDSGG 391

  Fly   220 PLVYNN----TLLGIVSWGTGCAREKYPGVYCSVPDVLDWL 256
            ||||:|    .::||||||..||..|.||||..|....||:
Human   392 PLVYDNHDIWYIVGIVSWGQSCALPKKPGVYTRVTKYRDWI 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lambdaTry	NP_610673.1	Tryp_SPc	35..255	CDD:214473	84/233 (36%)
lambdaTry	NP_610673.1	Tryp_SPc	36..259	CDD:238113	85/235 (36%)
TMPRSS11F	NP_997290.2	SEA	59..154	CDD:279699
		Tryp_SPc	205..432	CDD:214473	85/234 (36%)
		Tryp_SPc	206..435	CDD:238113	85/235 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910