DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lambdaTry and TMPRSS11A

DIOPT Version :9

Sequence 1:	NP_610673.1	Gene:	lambdaTry / 36214	FlyBaseID:	FBgn0043470	Length:	272	Species:	Drosophila melanogaster
Sequence 2:	NP_872412.3	Gene:	TMPRSS11A / 339967	HGNCID:	27954	Length:	421	Species:	Homo sapiens

Alignment Length:	247	Identity:	80/247 - (32%)
Similarity:	118/247 - (47%)	Gaps:	17/247 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 IPKLDGRIVGGQDTNITQYPHQISMRYRGNHRCGGTIYRSNQIISAAHCVNTLSGPENLTIVAGS 93
            :|....||..|.......:|.|.|::|...|:||.|:..:..:::||||......|...|:..|:
Human   183 VPLNVNRIASGVIAPKAAWPWQASLQYDNIHQCGATLISNTWLVTAAHCFQKYKNPHQWTVSFGT 247

  Fly    94 SNIWFPTGPQQELEVREIIIHPKYRTLNNDYDAAILILDGDFEFNDAVQPIELAKERPDHDTPVT 158
            .    ...|..:..||..|||.|||:...:||.|::.:.....|:|.::.|.|.:........:|
Human   248 K----INPPLMKRNVRRFIIHEKYRSAAREYDIAVVQVSSRVTFSDDIRQICLPEASASFQPNLT 308

  Fly   159 V--TGWGTTSEGGTISDVLQEVSVNVVDNSNCK--NAYSIMLTSRMLCAGVNGGGKDACQGDSGG 219
            |  ||:|....||...:.|:|..|.::.:..||  ..|...:...|.|||...|..|||:|||||
Human   309 VHITGFGALYYGGESQNDLREARVKIISDDVCKQPQVYGNDIKPGMFCAGYMEGIYDACRGDSGG 373

  Fly   220 PLVYNNT-----LLGIVSWGTGCAREKYPGVYCSVPDVLDWLVETVADKESV 266
            |||..:.     |:||||||..|.::..||||..|....:|    :|.|..:
Human   374 PLVTRDLKDTWYLIGIVSWGDNCGQKDKPGVYTQVTYYRNW----IASKTGI 421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lambdaTry	NP_610673.1	Tryp_SPc	35..255	CDD:214473	76/228 (33%)
lambdaTry	NP_610673.1	Tryp_SPc	36..259	CDD:238113	76/231 (33%)
TMPRSS11A	NP_872412.3	SEA	49..147	CDD:279699
		Tryp_SPc	189..415	CDD:214473	77/233 (33%)
		Tryp_SPc	190..418	CDD:238113	77/235 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910