DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lambdaTry and PRSS53

DIOPT Version :9

Sequence 1:	NP_610673.1	Gene:	lambdaTry / 36214	FlyBaseID:	FBgn0043470	Length:	272	Species:	Drosophila melanogaster
Sequence 2:	XP_011544118.1	Gene:	PRSS53 / 339105	HGNCID:	34407	Length:	623	Species:	Homo sapiens

Alignment Length:	292	Identity:	65/292 - (22%)
Similarity:	106/292 - (36%)	Gaps:	84/292 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 DGRIVGGQDTNITQYPHQISMRYRGNHRCGGTIYRSNQIISAAHCVNTLSGPE--NLTIVAGSSN 95
            :|..|.|      ::|.|.|:|.:|.|.|.|::.....:::||||....:..|  :.::|.||..
Human    40 EGNTVPG------EWPWQASVRRQGAHICSGSLVADTWVLTAAHCFEKAAATELNSWSVVLGSLQ 98

  Fly    96 IWFPTGPQQELEVREIIIHPKYRTLNNDYDAAILILDGDFEFNDAVQP---IELAKERPDHDTPV 157
            ....:...:|:.|..:.:...|...:...|.|:|.|         ..|   ..|...:|.|..|.
Human    99 REGLSPGAEEVGVAALQLPRAYNHYSQGSDLALLQL---------AHPTTHTPLCLPQPAHRFPF 154

  Fly   158 TVTGWGT-----TSEGG----------------TIS----------------------------D 173
            ..:.|.|     ||:|.                |:|                            .
Human   155 GASCWATGWDQDTSDGKCWPRLKLGEALCLPSVTVSAPNCPGFQSPLLPRSQTLAPAPSLSPAPG 219

  Fly   174 VLQEVSVNVVDNSNCKNAYSIMLTSR---------MLCAGVNGGGKDACQGDSGGPLVY-----N 224
            .|:.:.:.::....|...|: .|..|         |||.|...|.:..||||||||::.     :
Human   220 TLRNLRLRLISRPTCNCIYN-QLHQRHLSNPARPGMLCGGPQPGVQGPCQGDSGGPVLCLEPDGH 283

  Fly   225 NTLLGIVSWGTGCAREKYPGVYCSVPDVLDWL 256
            ....||:|:.:.||:|..|.:..:......||
Human   284 WVQAGIISFASSCAQEDAPVLLTNTAAHSSWL 315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lambdaTry	NP_610673.1	Tryp_SPc	35..255	CDD:214473	62/287 (22%)
lambdaTry	NP_610673.1	Tryp_SPc	36..259	CDD:238113	64/289 (22%)
PRSS53	XP_011544118.1	Tryp_SPc	42..316	CDD:238113	64/290 (22%)
		Tryp_SPc	43..314	CDD:214473	62/286 (22%)
		Tryp_SPc	359..>512	CDD:304450
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149446
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24276
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.940