DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lambdaTry and tmprss4b

DIOPT Version :9

Sequence 1:	NP_610673.1	Gene:	lambdaTry / 36214	FlyBaseID:	FBgn0043470	Length:	272	Species:	Drosophila melanogaster
Sequence 2:	NP_001119849.1	Gene:	tmprss4b / 327651	ZFINID:	ZDB-GENE-030131-5862	Length:	432	Species:	Danio rerio

Alignment Length:	267	Identity:	108/267 - (40%)
Similarity:	147/267 - (55%)	Gaps:	34/267 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VLGVGCSLADPIYRNEEVHIPKLDGRIVGGQDTNITQYPHQISMRYRGNHRCGGTIYRSNQIISA 74
            |:.|.||....:...:         |||||.:|:|..:|.|:|:::...|.|||::..::.||||
Zfish   185 VVSVSCSDCGEVVGED---------RIVGGVETSIEHWPWQVSLQFNHRHMCGGSLLSTSWIISA 240

  Fly    75 AHC----VNTLSGPENLTIVAGSSNIWFPTGPQQELEVREIIIHPKYRTLNNDYDAAILILDGDF 135
            |||    ...||   ..|:|.|.:.:....|    :.|..|:||..|..|.||:|.|:|.|....
Zfish   241 AHCFTGRTQELS---RWTVVLGQTKVMDVVG----VSVDMIVIHKDYNRLTNDFDIAMLKLTWPV 298

  Fly   136 EFNDAVQPIELAKERPDHDTPV----TVTGWGTTSEGGTISDVLQEVSVNVVDNSNCK--NAYSI 194
            :..:::.|:.|    |.|...:    .|||||...|||.:..|||:.||.:|:.|.|.  ..||.
Zfish   299 KTGESILPVCL----PPHQLAIKDMLVVTGWGLLKEGGALPTVLQKASVPLVNRSECSKPTIYSS 359

  Fly   195 MLTSRMLCAGVNGGGKDACQGDSGGPLVYNNT---LLGIVSWGTGCAREKYPGVYCSVPDVLDWL 256
            .:|.||||||...|..|||||||||||||.::   |:||||||.|||||..||||..|..:|||
Zfish   360 SITPRMLCAGFLQGNVDACQGDSGGPLVYLSSRWQLIGIVSWGVGCAREGKPGVYADVTQLLDW- 423

  Fly   257 VETVADK 263
            :.||.::
Zfish   424 IYTVMER 430

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lambdaTry	NP_610673.1	Tryp_SPc	35..255	CDD:214473	100/232 (43%)
lambdaTry	NP_610673.1	Tryp_SPc	36..259	CDD:238113	101/235 (43%)
tmprss4b	NP_001119849.1	SRCR_2	100..179	CDD:292133
		SRCR	105..>175	CDD:278931
		Tryp_SPc	201..424	CDD:214473	102/234 (44%)
		Tryp_SPc	202..427	CDD:238113	101/236 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	178	1.000	Domainoid score	I3517
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H80930
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100031
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.810