DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lambdaTry and F2

DIOPT Version :9

Sequence 1:	NP_610673.1	Gene:	lambdaTry / 36214	FlyBaseID:	FBgn0043470	Length:	272	Species:	Drosophila melanogaster
Sequence 2:	NP_075213.2	Gene:	F2 / 29251	RGDID:	61996	Length:	617	Species:	Rattus norvegicus

Alignment Length:	296	Identity:	94/296 - (31%)
Similarity:	137/296 - (46%)	Gaps:	55/296 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 GVG---CSLADPIYR--------NEEVHIPKLDGRIVGGQDTNITQYPHQISMRYRGNHR---CG 62
            |:|   |.|. |::.        .:|:....:|||||.|.|......|.|: |.:|.:.:   ||
  Rat   326 GLGEADCGLR-PLFEKKSLTDKTEKELLDSYIDGRIVEGWDAEKGIAPWQV-MLFRKSPQELLCG 388

  Fly    63 GTIYRSNQIISAAHCVNTLSGP------EN--LTIVAGSSNIWFPTGPQQELEVREIIIHPKYRT 119
            .::.....:::||||:  |..|      ||  |..:...|...:....::...:.:|.|||:|..
  Rat   389 ASLISDRWVLTAAHCI--LYPPWDKNFTENDLLVRIGKHSRTRYERNVEKISMLEKIYIHPRYNW 451

  Fly   120 LNN-DYDAAILILDGDFEFNDAVQPIELAKERPDHDTPVT---------VTGWGTTSEGGTIS-- 172
            ..| |.|.|:|.|.....|:|.:.|:.|    ||..|..:         |||||...|..|.:
  Rat   452 RENLDRDIALLKLKKPVPFSDYIHPVCL----PDKQTVTSLLQAGYKGRVTGWGNLRETWTTNIN 512

  Fly   173 ----DVLQEVSVNVVDNSNCKNAYSIMLTSRMLCAG--VNGGGK-DACQGDSGGPLV----YNNT 226
                .|||.|::.:|:...||.:..|.:|..|.|||  ||...: |||:||||||.|    ||:.
  Rat   513 EIQPSVLQVVNLPIVERPVCKASTRIRITDNMFCAGFKVNDTKRGDACEGDSGGPFVMKSPYNHR 577

  Fly   227 --LLGIVSWGTGCAREKYPGVYCSVPDVLDWLVETV 260
              .:||||||.||.|....|.|..|..:..|:.:.:
  Rat   578 WYQMGIVSWGEGCDRNGKYGFYTHVFRLKRWMQKVI 613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lambdaTry	NP_610673.1	Tryp_SPc	35..255	CDD:214473	85/255 (33%)
lambdaTry	NP_610673.1	Tryp_SPc	36..259	CDD:238113	85/258 (33%)
F2	NP_075213.2	GLA	25..89	CDD:214503
		KR	107..189	CDD:214527
		Kringle	215..292	CDD:278480
		Thrombin_light	312..359	CDD:286482	7/33 (21%)
		Tryp_SPc	359..608	CDD:214473	85/255 (33%)
		Tryp_SPc	360..612	CDD:238113	85/258 (33%)
		High affinity receptor-binding region which is also known as the TP508 peptide	547..569		13/21 (62%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910