DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lambdaTry and TMPRSS11E

DIOPT Version :9

Sequence 1:	NP_610673.1	Gene:	lambdaTry / 36214	FlyBaseID:	FBgn0043470	Length:	272	Species:	Drosophila melanogaster
Sequence 2:	NP_054777.2	Gene:	TMPRSS11E / 28983	HGNCID:	24465	Length:	423	Species:	Homo sapiens

Alignment Length:	236	Identity:	86/236 - (36%)
Similarity:	125/236 - (52%)	Gaps:	23/236 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 RIVGGQDTNITQYPHQISMRYRGNHRCGGTIYRSNQIISAAHCVNTLSGPENLTIVAGSSNIWFP 99
            |||||.:....::|.|.|:::.|:||||.|:..:..::|||||..|...|...|...|.:
Human   191 RIVGGTEVEEGEWPWQASLQWDGSHRCGATLINATWLVSAAHCFTTYKNPARWTASFGVT----- 250

  Fly   100 TGP-QQELEVREIIIHPKYRTLNNDYDAAILILDGDFEFNDAVQPIELAKERPDHD------TPV 157
            ..| :.:..:|.||:|.||:..::|||.::..|.....:.:||..:.|    ||..      ..:
Human   251 IKPSKMKRGLRRIIVHEKYKHPSHDYDISLAELSSPVPYTNAVHRVCL----PDASYEFQPGDVM 311

  Fly   158 TVTGWGTTSEGGTISDVLQEVSVNVVDNSNCK--NAYSIMLTSRMLCAGVNGGGKDACQGDSGGP 220
            .|||:|.....|...:.|::..|.::|.:.|.  .||:..:|.||||||...|..||||||||||
Human   312 FVTGFGALKNDGYSQNHLRQAQVTLIDATTCNEPQAYNDAITPRMLCAGSLEGKTDACQGDSGGP 376

  Fly   221 LVYNNT-----LLGIVSWGTGCAREKYPGVYCSVPDVLDWL 256
            ||.::.     |.||||||..||:...||||..|..:.||:
Human   377 LVSSDARDIWYLAGIVSWGDECAKPNKPGVYTRVTALRDWI 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lambdaTry	NP_610673.1	Tryp_SPc	35..255	CDD:214473	84/233 (36%)
lambdaTry	NP_610673.1	Tryp_SPc	36..259	CDD:238113	85/235 (36%)
TMPRSS11E	NP_054777.2	SEA	51..156	CDD:307516
TMPRSS11E	NP_054777.2	Tryp_SPc	192..420	CDD:238113	85/235 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910