DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lambdaTry and F11

DIOPT Version :9

Sequence 1:	NP_610673.1	Gene:	lambdaTry / 36214	FlyBaseID:	FBgn0043470	Length:	272	Species:	Drosophila melanogaster
Sequence 2:	XP_005262878.1	Gene:	F11 / 2160	HGNCID:	3529	Length:	626	Species:	Homo sapiens

Alignment Length:	246	Identity:	89/246 - (36%)
Similarity:	135/246 - (54%)	Gaps:	26/246 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 KLDGRIVGGQDTNITQYPHQISMRYRG---NHRCGGTIYRSNQIISAAHCVNTLSGPENLTIVAG 92
            |:..|||||..:...::|.|:::....   .|.|||:|..:..|::||||...:..|:.|.:.:|
Human   384 KIKPRIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYGVESPKILRVYSG 448

  Fly    93 SSNIWFPTGPQQELE-------VREIIIHPKYRTLNNDYDAAILILDGDFEFNDAVQPIELAKER 150
            ..|       |.|::       |:|||||.:|:...:.||.|:|.|:....:.|:.:||.| ..:
Human   449 ILN-------QSEIKEDTSFFGVQEIIIHDQYKMAESGYDIALLKLETTVNYTDSQRPICL-PSK 505

  Fly   151 PDHD---TPVTVTGWGTTSEGGTISDVLQEVSVNVVDNSNCKNAY-SIMLTSRMLCAGVNGGGKD 211
            .|.:   |...|||||.......|.:.||:..:.:|.|..|:..| ...:|.:|:|||...||||
Human   506 GDRNVIYTDCWVTGWGYRKLRDKIQNTLQKAKIPLVTNEECQKRYRGHKITHKMICAGYREGGKD 570

  Fly   212 ACQGDSGGPLVYNNT----LLGIVSWGTGCAREKYPGVYCSVPDVLDWLVE 258
            ||:|||||||...:.    |:||.|||.|||:.:.||||.:|.:.:||::|
Human   571 ACKGDSGGPLSCKHNEVWHLVGITSWGEGCAQRERPGVYTNVVEYVDWILE 621

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lambdaTry	NP_610673.1	Tryp_SPc	35..255	CDD:214473	85/237 (36%)
lambdaTry	NP_610673.1	Tryp_SPc	36..259	CDD:238113	87/241 (36%)
F11	XP_005262878.1	APPLE	20..103	CDD:128519
		APPLE	110..193	CDD:128519
		APPLE	200..283	CDD:128519
		APPLE	291..375	CDD:128519
		Tryp_SPc	388..619	CDD:214473	86/238 (36%)
		Tryp_SPc	389..619	CDD:238113	85/237 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100031
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810