DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lambdaTry and Prss12

DIOPT Version :9

Sequence 1:	NP_610673.1	Gene:	lambdaTry / 36214	FlyBaseID:	FBgn0043470	Length:	272	Species:	Drosophila melanogaster
Sequence 2:	NP_032965.1	Gene:	Prss12 / 19142	MGIID:	1100881	Length:	761	Species:	Mus musculus

Alignment Length:	267	Identity:	89/267 - (33%)
Similarity:	132/267 - (49%)	Gaps:	31/267 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VLGVGCSLADPIYRNEEVHIPKLDGRIVGGQDTNITQYPHQISMRYRGNH-----RCGGTIYRSN 69
            :|..||.|. .::|.::        ||:||.::....:|.|.|:|.|..|     .||.|:..|.
Mouse   500 MLSSGCGLR-LLHRRQK--------RIIGGNNSLRGAWPWQASLRLRSAHGDGRLLCGATLLSSC 555

  Fly    70 QIISAAHCVNTL-SGPENLTIVAGSSNIWFPTGPQQELEVREIIIHPKYRTLNNDYDAAILILDG 133
            .:::||||.... :...:..:..|..:...|...:||:.|::|:||..||...:|||.|::.|.|
Mouse   556 WVLTAAHCFKRYGNNSRSYAVRVGDYHTLVPEEFEQEIGVQQIVIHRNYRPDRSDYDIALVRLQG 620

  Fly   134 DFE----FNDAVQP--IELAKERPDHD-TPVTVTGWGTTSEGGTISDVLQEVSVNVVDNSNCKNA 191
            ..|    .:..|.|  :.|.:|||... :...:||||.|  |...|..||:.:|.::....||..
Mouse   621 PGEQCARLSTHVLPACLPLWRERPQKTASNCHITGWGDT--GRAYSRTLQQAAVPLLPKRFCKER 683

  Fly   192 YSIMLTSRMLCAG--VNGGGKDACQGDSGGPLVYNN-----TLLGIVSWGTGCAREKYPGVYCSV 249
            |..:.|.||||||  ......|:|||||||||:...     .:.|:.|||.||..:..||||..|
Mouse   684 YKGLFTGRMLCAGNLQEDNRVDSCQGDSGGPLMCEKPDESWVVYGVTSWGYGCGVKDTPGVYTRV 748

  Fly   250 PDVLDWL 256
            |..:.|:
Mouse   749 PAFVPWI 755

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lambdaTry	NP_610673.1	Tryp_SPc	35..255	CDD:214473	83/239 (35%)
lambdaTry	NP_610673.1	Tryp_SPc	36..259	CDD:238113	83/241 (34%)
Prss12	NP_032965.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	25..87
		KR	83..159	CDD:214527
		SR	166..265	CDD:214555
		SRCR	171..265	CDD:278931
		SR	273..372	CDD:214555
		SRCR	278..371	CDD:278931
		SR	386..485	CDD:214555
		SRCR	396..485	CDD:278931
		Zymogen activation region	505..516		3/19 (16%)
		Tryp_SPc	516..755	CDD:214473	83/240 (35%)
		Tryp_SPc	517..758	CDD:238113	83/241 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910