DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lambdaTry and TMPRSS6

DIOPT Version :9

Sequence 1:	NP_610673.1	Gene:	lambdaTry / 36214	FlyBaseID:	FBgn0043470	Length:	272	Species:	Drosophila melanogaster
Sequence 2:	NP_001275929.1	Gene:	TMPRSS6 / 164656	HGNCID:	16517	Length:	824	Species:	Homo sapiens

Alignment Length:	282	Identity:	93/282 - (32%)
Similarity:	132/282 - (46%)	Gaps:	53/282 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 CSLADPIYRNEEVHIPKLDGRIVGGQDTNITQYPHQISMRYRGNHRCGGTIYRSNQIISAAHCV- 78
            |.|..|            ..|||||..::..::|.|.|::.||.|.|||.:.....:|:||||.
Human   559 CGLQGP------------SSRIVGGAVSSEGEWPWQASLQVRGRHICGGALIADRWVITAAHCFQ 611

  Fly    79 -NTLSGPENLTIVAGSSNIW----FPTGPQQELEVREIIIHPKYRTLNNDYDAAILILDGDFEFN 138
             ::::.....|:..|  .:|    :|  .:...:|..:::||.:...::|||.|:|.||.....:
Human   612 EDSMASTVLWTVFLG--KVWQNSRWP--GEVSFKVSRLLLHPYHEEDSHDYDVALLQLDHPVVRS 672

  Fly   139 DAVQPIELAKERPDHDTP---VTVTGWGTTSEGG----------------------TISDVLQEV 178
            .||:|:.| ..|.....|   ..:||||...||.                      .||:.||:|
Human   673 AAVRPVCL-PARSHFFEPGLHCWITGWGALREGALRADAVALFYGWRNQGSETCCCPISNALQKV 736

  Fly   179 SVNVVDNSNCKNAYSIMLTSRMLCAGVNGGGKDACQGDSGGPLVYNNT-----LLGIVSWGTGCA 238
            .|.::....|...|...:|.||||||...|.|||||||||||||....     |.|:||||.||.
Human   737 DVQLIPQDLCSEVYRYQVTPRMLCAGYRKGKKDACQGDSGGPLVCKALSGRWFLAGLVSWGLGCG 801

  Fly   239 REKYPGVYCSVPDVLDWLVETV 260
            |..|.|||..:..|:.|:.:.|
Human   802 RPNYFGVYTRITGVISWIQQVV 823

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lambdaTry	NP_610673.1	Tryp_SPc	35..255	CDD:214473	88/255 (35%)
lambdaTry	NP_610673.1	Tryp_SPc	36..259	CDD:238113	88/258 (34%)
TMPRSS6	NP_001275929.1	SEA	77..177	CDD:307516
		CUB	326..440	CDD:238001
		LDLa	450..480	CDD:238060
		LDLa	486..516	CDD:238060
		Ldl_recept_a	520..557	CDD:278486
		Tryp_SPc	568..822	CDD:238113	88/258 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100031
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810