DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lambdaTry and PRSS36

DIOPT Version :9

Sequence 1:	NP_610673.1	Gene:	lambdaTry / 36214	FlyBaseID:	FBgn0043470	Length:	272	Species:	Drosophila melanogaster
Sequence 2:	NP_775773.2	Gene:	PRSS36 / 146547	HGNCID:	26906	Length:	855	Species:	Homo sapiens

Alignment Length:	254	Identity:	83/254 - (32%)
Similarity:	116/254 - (45%)	Gaps:	19/254 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 PKLDGRIVGGQDTNITQYPHQISMRYRGNHRCGGTIYRSNQIISAAHCV---NTLSGPENLTIVA 91
            |:...|||||.:.....:|.|:|:.:.|.|.|||::...:.::|||||.   .||......:::.
Human    41 PEPSARIVGGSNAQPGTWPWQVSLHHGGGHICGGSLIAPSWVLSAAHCFMTNGTLEPAAEWSVLL 105

  Fly    92 GSSNIWFPTGPQQELEVREIIIHPKYRTLNNDYDAAILILDGDFEFNDAVQPIEL--AKERPDHD 154
            |..:...|........|..|::...|..:....|.|:|.|........||.|:.|  |..|..|.
Human   106 GVHSQDGPLDGAHTRAVAAIVVPANYSQVELGADLALLRLASPASLGPAVWPVCLPRASHRFVHG 170

  Fly   155 TPVTVTGWGTTSEGG--TISDVLQEVSVNVVDNSNCKNAYS--------IMLTSRMLCAGVNGGG 209
            |....||||...|..  .:..|||||.:.::..:.|:..||        :.:...|||||...|.
Human   171 TACWATGWGDVQEADPLPLPWVLQEVELRLLGEATCQCLYSQPGPFNLTLQILPGMLCAGYPEGR 235

  Fly   210 KDACQGDSGGPLVYNN----TLLGIVSWGTGCAREKYPGVYCSVPDVLDWLVETVADKE 264
            :|.||||||||||...    ...||.|:|.||.|...|||:.:|.....|:.|.|...|
Human   236 RDTCQGDSGGPLVCEEGGRWFQAGITSFGFGCGRRNRPGVFTAVATYEAWIREQVMGSE 294

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lambdaTry	NP_610673.1	Tryp_SPc	35..255	CDD:214473	78/238 (33%)
lambdaTry	NP_610673.1	Tryp_SPc	36..259	CDD:238113	78/241 (32%)
PRSS36	NP_775773.2	Tryp_SPc	46..286	CDD:214473	78/239 (33%)
		Tryp_SPc	47..289	CDD:238113	78/241 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	292..316		1/3 (33%)
		Tryp_SPc	330..538	CDD:304450
		Tryp_SPc	601..783	CDD:304450
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149418
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100031
Panther	1	1.100	-	-	O	PTHR24276
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840