DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lambdaTry and MASP2

DIOPT Version :9

Sequence 1:	NP_610673.1	Gene:	lambdaTry / 36214	FlyBaseID:	FBgn0043470	Length:	272	Species:	Drosophila melanogaster
Sequence 2:	NP_006601.2	Gene:	MASP2 / 10747	HGNCID:	6902	Length:	686	Species:	Homo sapiens

Alignment Length:	248	Identity:	77/248 - (31%)
Similarity:	115/248 - (46%)	Gaps:	24/248 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 GRIVGGQDTNITQYPHQISMRYRGNHRCGGTIYRSNQIISAAHCV-NTLSGPENLTIVAGSSNIW 97
            |||.|||......:|.|:.:  .|.....|.:...|.:::|||.| ........|.|..|:....
Human   443 GRIYGGQKAKPGDFPWQVLI--LGGTTAAGALLYDNWVLTAAHAVYEQKHDASALDIRMGTLKRL 505

  Fly    98 FPTGPQQELEVREIIIHPKY-RTLNNDYDAAILILDGDFEFNDAVQPIELAKERPDH----DTPV 157
            .|...|...|.  :.||..| .....|.|.|::.|:.....|..:.||.|.::..:.    |...
Human   506 SPHYTQAWSEA--VFIHEGYTHDAGFDNDIALIKLNNKVVINSNITPICLPRKEAESFMRTDDIG 568

  Fly   158 TVTGWGTTSEGGTISDVLQEVSVNVVDNSNCKNAYSI------MLTSRMLCAGVNGGGKDACQGD 216
            |.:|||.| :.|.::..|..|.:.:||:..|..||..      .:|:.|||||:..||||:|:||
Human   569 TASGWGLT-QRGFLARNLMYVDIPIVDHQKCTAAYEKPPYPRGSVTANMLCAGLESGGKDSCRGD 632

  Fly   217 SGGPLVYNNT------LLGIVSWGT-GCAREKYPGVYCSVPDVLDWLVETVAD 262
            |||.||:.::      :.||||||: .|......|||..|.:.:.|:...::|
Human   633 SGGALVFLDSETERWFVGGIVSWGSMNCGEAGQYGVYTKVINYIPWIENIISD 685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lambdaTry	NP_610673.1	Tryp_SPc	35..255	CDD:214473	74/238 (31%)
lambdaTry	NP_610673.1	Tryp_SPc	36..259	CDD:238113	74/241 (31%)
MASP2	NP_006601.2	CUB	28..134	CDD:214483
		EGF_CA	138..176	CDD:214542
		CUB	184..293	CDD:278839
		CCP	300..361	CDD:214478
		Sushi	366..430	CDD:278512
		Tryp_SPc	444..679	CDD:214473	74/239 (31%)
		Tryp_SPc	445..682	CDD:238113	74/241 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910