DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lambdaTry and tmprss2.2

DIOPT Version :9

Sequence 1:	NP_610673.1	Gene:	lambdaTry / 36214	FlyBaseID:	FBgn0043470	Length:	272	Species:	Drosophila melanogaster
Sequence 2:	XP_002941330.2	Gene:	tmprss2.2 / 100493729	XenbaseID:	XB-GENE-22065949	Length:	521	Species:	Xenopus tropicalis

Alignment Length:	241	Identity:	90/241 - (37%)
Similarity:	126/241 - (52%)	Gaps:	27/241 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 RIVGGQDTNITQYPHQISMRYRGNHRCGGTIYRSNQIISAAHCVNTLSG----PENLTIVAGSSN 95
            |||||.......:..|:.:||.....|||:|.....|::|||||....|    .....:.||:..
Frog   281 RIVGGTYAAYGNWLWQVGLRYNTGILCGGSIISPKWIVTAAHCVYGTDGFLLSASGWRVFAGTLT 345

  Fly    96 I---WFPTGPQQELEVREIIIHPKYRTLNNDYDAAILILDGDFEFNDAVQPIELAKERPD----- 152
            :   :..:|    ..|..||.||.|:|.:||.|.|::.|.....|....||:.|    |:
Frog   346 LPSYYDSSG----YLVERIIPHPGYKTSSNDNDIALMELSNGITFGYNTQPVCL----PNAGMFW 402

  Fly   153 -HDTPVTVTGWGTTSEGGTISDVLQEVSVNVVDNSNCKN--AYSIMLTSRMLCAGVNGGGKDACQ 214
             ..||..::||||||:||:.|..||..:|.::|::.|..  .|:..:|:.|:|||...||.|:||
Frog   403 SSGTPCWISGWGTTSQGGSASTYLQYAAVQLIDSNVCNQNYVYNGQITASMICAGYLSGGVDSCQ 467

  Fly   215 GDSGGPLV--YNNT--LLGIVSWGTGCAREKYPGVYCSVPDVLDWL 256
            ||||||||  .|.|  |:|..|||.|||:...||||.::...|.|:
Frog   468 GDSGGPLVTKTNGTWWLVGDTSWGYGCAQPNKPGVYGNMTSFLGWI 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lambdaTry	NP_610673.1	Tryp_SPc	35..255	CDD:214473	89/238 (37%)
lambdaTry	NP_610673.1	Tryp_SPc	36..259	CDD:238113	89/240 (37%)
tmprss2.2	XP_002941330.2	LDLa	<111..134	CDD:238060
		LDLa	145..174	CDD:238060
		SRCR_2	179..274	CDD:292133
		Tryp_SPc	281..513	CDD:214473	89/239 (37%)
		Tryp_SPc	282..513	CDD:238113	88/238 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000