DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ING1 and bip2

DIOPT Version :9

Sequence 1:	NP_005528.4	Gene:	ING1 / 3621	HGNCID:	6062	Length:	422	Species:	Homo sapiens
Sequence 2:	NP_651923.2	Gene:	bip2 / 43793	FlyBaseID:	FBgn0026262	Length:	1406	Species:	Drosophila melanogaster

Alignment Length:	328	Identity:	65/328 - (19%)
Similarity:	112/328 - (34%)	Gaps:	102/328 - (31%)

- Green bases have known domain annotations that are detailed below.

Human   141 AVAVIPGLWARGRGCSSDRLPRPAGPARRQFQAASLLTRGWGRAWPWKQILKELDECYERFSRET 205
            ::.:.|.|.|...|.|.:::|:             |..:..|::..:....||:          |
  Fly  1133 SMTINPSLGAATSGISPNQIPK-------------LTLKLSGKSTLFSSSEKEM----------T 1174

Human   206 DGAQKRRMLHCVQRALIRSQELGDEKIQIVSQMVELVENRTRQVDSHVELFE--------AQQEL 262
            |..:.:      |..::.|                  ||:.|:.|:..||..        .:.:.
  Fly  1175 DAGKLK------QTTILSS------------------ENKKRERDNSPELARFSPLVTGPPKNKQ 1215

Human   263 GDT--AGNSGKAGADRPKGEAAAQADKPNSKRSRRQR---NNENRENASSN-------------- 308
            .:|  .|||..|....|...|......|.|:.|....   :|.|..|.:|:
  Fly  1216 SETLHLGNSSTAVLPVPSPVAVRAVQLPVSQTSSNSAGWLSNPNNSNTASSTLSASSVLLPQQLM 1280

Human   309 ---HDHDD-------GASGTPKE-----KKAKTSKKKKRSKAKAEREASPADLPIDPNEPTYC-L 357
               |...:       .::||..:     ....||::...:...||.....:.:..:.|....| .
  Fly  1281 LAPHTIMNNFVPAMCNSTGTVSKSGLCSSPPNTSEENANAMQIAESSRPSSYVDAEGNRIWICPA 1345

Human   358 CNQVSYGE-MIGCDNDECPIEWFHFSCVGLNHKPKGK--WYCPKCRGENEKTMDKALEKSKKERA 419
            |.:|..|. |||||..:.   |:|:.|||:...||..  |:|..|      ...|.:..|:|::.
  Fly  1346 CGKVDDGSAMIGCDGCDA---WYHWICVGITFAPKDNDDWFCRVC------VTKKRIHGSEKKKR 1401

Human   420 YNR 422
            .|:
  Fly  1402 RNK 1404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ING1	NP_005528.4	ING	<189..254	CDD:289749	10/64 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	261..349		21/121 (17%)
		PHD_ING1_2	355..399	CDD:277059	18/47 (38%)
		PBR. /evidence=ECO:0000250\|UniProtKB:Q9H160	405..422		3/16 (19%)
bip2	NP_651923.2	BTP	4..80	CDD:128846
bip2	NP_651923.2	PHD_TAF3	1342..1387	CDD:276997	18/47 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5034
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900