DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fpps and PDSS1

DIOPT Version :9

Sequence 1:	NP_477380.1	Gene:	Fpps / 36209	FlyBaseID:	FBgn0025373	Length:	419	Species:	Drosophila melanogaster
Sequence 2:	NP_055132.2	Gene:	PDSS1 / 23590	HGNCID:	17759	Length:	415	Species:	Homo sapiens

Alignment Length:	356	Identity:	65/356 - (18%)
Similarity:	133/356 - (37%)	Gaps:	64/356 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 RDFMAVFPDLVRDITTVTKAYNCSDAAKWFAQVLQYNVPRGKKNRGILTVLTYKNLVPTQDLTPE 149
            ||...::.|:.:::...|.  ...:.:::      |...:||..|.|:..|    :....::...
Human   101 RDLKGLYEDIRKELLISTS--ELKEMSEY------YFDGKGKAFRPIIVAL----MARACNIHHN 153

  Fly   150 NIKLAQ----YLGWCVEMLQSFFIISDDVMDNSTTRRGQPCWHKVENVGLTAINDALMIENAMYA 210
            |.:..|    .:....||:.:..::.|||:|::::|||:...:|:.......:...|::..|..|
Human   154 NSRHVQASQRAIALIAEMIHTASLVHDDVIDDASSRRGKHTVNKIWGEKKAVLAGDLILSAASIA 218

  Fly   211 ILKKHFSHLDCYVALMELFHEITYITTCGQSLDQL------------NSNRCVSEFTMENYKAIV 263
            :.:               ....|.|:...|.::.|            |.|...:.:..:.:|
Human   219 LAR---------------IGNTTVISILTQVIEDLVRGEFLQLGSKENENERFAHYLEKTFK--- 265

  Fly   264 ENKTAYYSFYLPFALALHLAGYKDAE----AFRQSKTILLEMGNFFQVQDDFLDCFGNPEVTGK- 323
              |||  |.......|:.:.|..|..    |::..|.:    |..||:.||.||.....:..||
Human   266 --KTA--SLIANSCKAVSVLGCPDPVVHEIAYQYGKNV----GIAFQLIDDVLDFTSCSDQMGKP 322

  Fly   324 IGTDIQDNKCSWLAVVAMQRANVEQKQIMVDCYGKEEPAKVERVKE-LYKELGLPSTYAIFEEES 387
            ...|::....:...:.|.|:.......||   .....|..|:|.:: :.:..|:..|..:.::..
Human   323 TSADLKLGLATGPVLFACQQFPEMNAMIM---RRFSLPGDVDRARQYVLQSDGVQQTTYLAQQYC 384

  Fly   388 YNMIKTHIQQTSRGVPHQTFLQILNKIYQRD 418
            :..|: .|.:..........:|:...:..||
Human   385 HEAIR-EISKLRPSPERDALIQLSEIVLTRD 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fpps	NP_477380.1	polyprenyl_synt	119..377	CDD:278763	55/279 (20%)
PDSS1	NP_055132.2	PLN02890	6..415	CDD:178478	65/356 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	16..35
		Isoprenoid_Biosyn_C1	102..413	CDD:294142	62/352 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0142
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810