Protein Alignment Fpps and FDPS

DIOPT Version :10

• Sequence 1: NP_477380.1
• Gene: Fpps / 36209
• FlyBaseID: FBgn0025373
• Length: 419
• Species: Drosophila melanogaster
• Sequence 2: NP_001995.1
• Gene: FDPS / 2224
• HGNCID: 3631
• Length: 419
• Species: Homo sapiens
• Alignment Length: 343
• Identity: 159/343 - (46%)
• Similarity: 225/343 - (65%)
• Gaps: 4/343 - (1%)

  Fly    79 VSKDESRDFMAVFPDLVRDITTVTKAY-NCSDAAKWFAQVLQYNVPRGKKNRGILTVLTYKNLVP 142
            |...|.:||:..|..:||.:|.....: ...||.....:||:||...||.|||:..|:.::.||.
Human    75 VYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAIGGKYNRGLTVVVAFRELVE 139

  Fly   143 TQDLTPENIKLAQYLGWCVEMLQSFFIISDDVMDNSTTRRGQPCWHKVENVGLTAINDALMIENA 207
            .:....::::.|..:|||||:||:||:::||:||:|.|||||.||::...|||.|||||.::|..
Human   140 PRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRGQICWYQKPGVGLDAINDANLLEAC 204

  Fly   208 MYAILKKHFSHLDCYVALMELFHEITYITTCGQSLDQLNS---NRCVSEFTMENYKAIVENKTAY 269
            :|.:||.:......|:.|:|||.:.:|.|..||:||.|.:   |..:..||.:.||:||:.|||:
Human   205 IYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLDLLTAPQGNVDLVRFTEKRYKSIVKYKTAF 269

  Fly   270 YSFYLPFALALHLAGYKDAEAFRQSKTILLEMGNFFQVQDDFLDCFGNPEVTGKIGTDIQDNKCS 334
            ||||||.|.|:::||....:....:|.||||||.|||:|||:||.||:|.|||||||||||||||
Human   270 YSFYLPIAAAMYMAGIDGEKEHANAKKILLEMGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCS 334

  Fly   335 WLAVVAMQRANVEQKQIMVDCYGKEEPAKVERVKELYKELGLPSTYAIFEEESYNMIKTHIQQTS 399
            ||.|..:|||..||.||:.:.||::|..||.|||.||:||.||:.:..:||:||:.|...|:|.:
Human   335 WLVVQCLQRATPEQYQILKENYGQKEAEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYA 399

  Fly   400 RGVPHQTFLQILNKIYQR 417
            ..:|...||.:..|||:|
Human   400 APLPPAVFLGLARKIYKR 417

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fpps	NP_477380.1	polyprenyl_synt	112..373	CDD:459773	131/263 (50%)
FDPS	NP_001995.1	polyprenyl_synt	108..373	CDD:459773	131/264 (50%)