DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7741 and mug161

DIOPT Version :9

Sequence 1:	NP_610670.2	Gene:	CG7741 / 36208	FlyBaseID:	FBgn0033615	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	NP_593012.1	Gene:	mug161 / 2541461	PomBaseID:	SPAC1F3.09	Length:	561	Species:	Schizosaccharomyces pombe

Alignment Length:	602	Identity:	138/602 - (22%)
Similarity:	236/602 - (39%)	Gaps:	138/602 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 ILVVGDVRGRFKQLFQRVEQVNKKAGPFEILCCVGDFFGEDK-QNEELIAYKNGFKHITVPTY-- 89
            :||:|...||..:..:.:..::|:.| |:...|:|:.|...: .:.:::..||....:.:|.|
pombe    12 VLVIGSADGRVIEAIEYIADLHKQHG-FKFAICLGNLFSHKRTTSADVVKLKNEKVKVPIPVYFG 75

  Fly    90 ---------------ILGPNQREHEKYFENLTDGEICTNLTYLGRRGVYTLSSGVKIAYLSG--- 136
                           :.||               |:..||..:|..|.........||.|.|
pombe    76 VGTAGLPESIISHMAMYGP---------------EVAPNLFCMGICGFMKTFYKFTIAQLGGSYN 125

  Fly   137 ----LEAQGTADSAGSEHEFTKADVIAVRNSCLVSKNCSTEYRGVDVLLTSQWPFGMQEKENATA 197
                .:.....:.:.:|..|.::||..      :||.|       |:|.:|:||..:||......
pombe   126 EEKYYQPPEKFEQSLNEKCFHRSDVQK------LSKRC-------DILFSSEWPEDVQENSTLPE 177

  Fly   198 SKL------VSFLCREIKPRYHFCAING-THYESAPFRMPKDETTQFELCTRFISLAEVGNAEKA 255
            .||      ::.|.....|:|.|  :.| .:||..|::............|.|::||...|::..
pombe   178 RKLPKGCMPLAALAANCMPQYFF--VPGPVYYEREPYKNSAAINVNTGTVTHFVALAPFKNSKNE 240

  Fly   256 KYIYALSLKPVDKSRLLDLAQKTTNEIPCPF----IGL--------------------------- 289
            |:.||.:|.|:....:.......|   ..||    |.|
pombe   241 KFSYAFTLYPLTTEYMQPAPPNCT---ASPFEHRPIPLKRASEDQIIPQQTNKFHKSKSSTALFK 302

  Fly   290 ---DLGGAIGKNDSSENRQYFYDMDGGRRKRQGGD--NNKRDKRPRIPQIEQDKCWFCLSSPDVE 349
               |...::.|...||:.....::    .|.:.|.  ||:|.|      :....|:||||:|:|.
pombe   303 SKKDSSSSLNKMHKSESHSALNNL----HKSESGTSLNNRRSK------VGPGSCFFCLSNPNVA 357

  Fly   350 KHLIITVGEHFYLALAKGPI-----------NKHHVMILSTKHVPCAAQLSPDDWK----ELNKF 399
            .|||:.:|...|:||.|||:           :..||:|:...|....:.||...::    |:|:|
pombe   358 LHLIVAIGNEAYMALPKGPLTTTASNTPALASSGHVLIIPIAHASALSTLSDTSYEKTLNEMNRF 422

  Fly   400 KAALRKFFKTL-GQVVCFTERHYKSVHLQINALAFEEGYAWKIKHSFEDKAEEFNLEFETLPALD 463
            :.|:...:... ...:.:.......|||....:...:..:.:|:..|.:.|:|...:||
pombe   423 RKAVTDMYNACDSDALVYEISRANGVHLHWQMIPIPKISSHRIESVFLEMAKEAGYDFE------ 481

  Fly   464 SEKMLPEMGPYFLAELPDDSTLITR-QMK-HFPIHFARDVFCSENLLNCDEKVNWKDCLLDKDEE 526
            ...:.|....||...||....||.| |:: .|.:.|.|.  .:..:|..:::|:|:.|:..:|||
pombe   482 ERDVEPHELNYFRVFLPSGKILIHRLQLRERFDLQFGRR--AAAKILGLEDRVDWRKCVQTEDEE 544

  Fly   527 VAYVEDFRKAFAPFDFT 543
            .|..|.|:..|.|:|||
pombe   545 KAESEAFKMCFKPYDFT 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7741	NP_610670.2	MPP_CWF19_N	29..249	CDD:277326	54/251 (22%)
		HIT_like	320..428	CDD:294158	35/125 (28%)
		CwfJ_C_2	466..543	CDD:282523	25/78 (32%)
mug161	NP_593012.1	MPP_CWF19_N	13..234	CDD:277326	54/251 (22%)
		MPP_superfamily	<92..>166	CDD:301300	21/101 (21%)
		CwfJ_C_1	334..470	CDD:282524	35/141 (25%)
		CwfJ_C_2	483..561	CDD:282523	25/79 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	60	1.000	Domainoid score	I3028
eggNOG	1	0.900	-	-		E1_KOG2476
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	133	1.000	Inparanoid score	I1412
OMA	1	1.010	-	-		QHG55395
OrthoFinder	1	1.000	-	-		FOG0004146
OrthoInspector	1	1.000	-	-		oto102160
orthoMCL	1	0.900	-	-		OOG6_103314
Panther	1	1.100	-	-	LDO	PTHR12072
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R771
SonicParanoid	1	1.000	-	-		X2899
TreeFam	1	0.960	-	-
	12	11.860