DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dare and FDXR

DIOPT Version :9

Sequence 1:	NP_477150.1	Gene:	dare / 36203	FlyBaseID:	FBgn0015582	Length:	466	Species:	Drosophila melanogaster
Sequence 2:	NP_001244941.2	Gene:	FDXR / 2232	HGNCID:	3642	Length:	534	Species:	Homo sapiens

Alignment Length:	509	Identity:	224/509 - (44%)
Similarity:	303/509 - (59%)	Gaps:	77/509 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 QSTTPTKRICIVGAGPAGFYAAQLILKQLD--------------------------------NC- 55
            |..||  :||:||:||||||.||.:||:::                                :|
Human    35 QEKTP--QICVVGSGPAGFYTAQHLLKRVEALCSQPRVLNSPALSGEGEDLGASQPLSLGPTSCH 97

  Fly    56 ---------VVDVVEKLPVPFGLVRFGVAPDHPEVKNVINTFTKTAEHPRLRYFGNISLGTDVSL 111
                     .||:.||.||||||||||||||||||||||||||:||...|..::||:.:|.||::
Human    98 PVPQQHPQAHVDIYEKQPVPFGLVRFGVAPDHPEVKNVINTFTQTAHSGRCAFWGNVEVGRDVTV 162

  Fly   112 RELRDRYHAVLLTYGADQDRQLELENEQLDNVISARKFVAWYNGLPGAENLAPDLSGRDVTIVGQ 176
            .||::.||||:|:|||:..|.||:..|:|..|.|||.||.||||||..:.|.||||.....|:||
Human   163 PELQEAYHAVVLSYGAEDHRALEIPGEELPGVCSARAFVGWYNGLPENQELEPDLSCDTAVILGQ 227

  Fly   177 GNVAVDVARMLLSPLDALKTTDTTEYALEALSCSQVERVHLVGRRGPLQAAFTIKELREMLKLPN 241
            ||||:||||:||:|.:.|:.||.|:.||..|..|:|:.|.|||||||||.||||||||||::||.
Human   228 GNVALDVARILLTPPEHLERTDITKAALGVLRQSRVKTVWLVGRRGPLQVAFTIKELREMIQLPG 292

  Fly   242 VDTRWRTEDFSGIDMQLDKLQRPRKRLTELMLKSLKEQ-------GRISGSKQFLPIFLRAPKAI 299
            ........||.|:..::.::.|||||||||:|::..|:       .:.|.|:.:...|.|:|:.:
Human   293 ARPILDPVDFLGLQDKIKEVPRPRKRLTELLLRTATEKPGPAEAARQASASRAWGLRFFRSPQQV 357

  Fly   300 APGE-------MEFSVTELQ--QEA--AVPTSSTERLPSHLILRSIGYKSSCVDTGINFDTRRGR 353
            .|..       :..:||.|:  .||  ||||...|.||..|:|.||||||..||..:.||::.|.
Human   358 LPSPDGRRAAGVRLAVTRLEGVDEATRAVPTGDMEDLPCGLVLSSIGYKSRPVDPSVPFDSKLGV 422

  Fly   354 VHNINGRILKDDATGEVDPGLYVAGWLGTGPTGVIVTTMNGAFAVAKTICDDINTNALDTSSVKP 418
            :.|:.||::      :| ||||.:||:..||||||.|||..:|...:.:..|:....| .|..:|
Human   423 IPNVEGRVM------DV-PGLYCSGWVKRGPTGVIATTMTDSFLTGQMLLQDLKAGLL-PSGPRP 479

  Fly   419 GYDA-------DGKRVVTWDGWQRINDFESAAGKAKGKPREKIVSIEEMLRVAG 465
            ||.|       .|.|.|::..|::::..|.|.|:..||||||:|..:||||:.|
Human   480 GYAAIQALLSSRGVRPVSFSDWEKLDAEEVARGQGTGKPREKLVDPQEMLRLLG 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dare	NP_477150.1	PLN02852	10..465	CDD:215457	223/507 (44%)
dare	NP_477150.1	NAD_binding_8	34..98	CDD:290186	46/105 (44%)
FDXR	NP_001244941.2	PLN02852	30..530	CDD:215457	221/504 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159304
Domainoid	1	1.000	195	1.000	Domainoid score	I3145
eggNOG	1	0.900	-	-		E1_COG0493
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3033
Inparanoid	1	1.050	389	1.000	Inparanoid score	I2015
Isobase	1	0.950	-	0.820802	Normalized mean entropy	S1767
OMA	1	1.010	-	-		QHG63565
OrthoDB	1	1.010	-	-		D1324510at2759
OrthoFinder	1	1.000	-	-		FOG0004755
OrthoInspector	1	1.000	-	-		oto89756
orthoMCL	1	0.900	-	-		OOG6_101920
Panther	1	1.100	-	-	LDO	PTHR11938
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R27
SonicParanoid	1	1.000	-	-		X3346
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750