DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dare and fdxr

DIOPT Version :9

Sequence 1:	NP_477150.1	Gene:	dare / 36203	FlyBaseID:	FBgn0015582	Length:	466	Species:	Drosophila melanogaster
Sequence 2:	XP_003199702.2	Gene:	fdxr / 100536115	ZFINID:	ZDB-GENE-130613-2	Length:	486	Species:	Danio rerio

Alignment Length:	472	Identity:	232/472 - (49%)
Similarity:	301/472 - (63%)	Gaps:	37/472 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 RGLHTSSARLQVIQSTTPTKRICIVGAGPAGFYAAQLILKQLDNCVVDVVEKLPVPFGLVRFGVA 75
            |||.:.||            |:|:||.||||||.||.:||...:.|||:.|:|||||||||||||
Zfish    32 RGLSSVSA------------RVCVVGGGPAGFYTAQQLLKARQDAVVDIYERLPVPFGLVRFGVA 84

  Fly    76 PDHPEVKNVINTFTKTAEHPRLRYFGNISLGTDVSLRELRDRYHAVLLTYGADQDRQLELENEQL 140
            ||||||||||||||:||:|.|..:.||:::|.||::.|||..||||:|:|||:.:|.:.:..|.|
Zfish    85 PDHPEVKNVINTFTQTAQHERCSFHGNVNVGKDVTIEELRQAYHAVVLSYGAEGNRSMGIPGEDL 149

  Fly   141 DNVISARKFVAWYNGLPGAENLAPDLSGRDVTIVGQGNVAVDVARMLLSPLDALKTTDTTEYALE 205
            .||.||:.||.||||:|....|.||||.....::||||||:||||:||||:|.||.||.|:.|||
Zfish   150 CNVFSAKDFVGWYNGVPSNTELCPDLSCETAVVLGQGNVALDVARILLSPVDMLKETDITQNALE 214

  Fly   206 ALSCSQVERVHLVGRRGPLQAAFTIKELREMLKLPNVDTRWRTEDFSGIDMQLDKLQRPRKRLTE 270
            ||:.|.|.||.:||||||||.|.||||||||:.|||........||.||...|.:|.|||||||:
Zfish   215 ALTGSNVRRVLIVGRRGPLQIACTIKELREMVNLPNTRADMLPADFEGIAEALKELPRPRKRLTD 279

  Fly   271 LMLKSLKEQGRISGSKQFLPIFLRAPKAIAPG-------EMEFSVTELQQEA----AVPTSSTER 324
            ||:|::||.|.....|.:...|.|:|..:..|       .:..::.:|:.|.    :|||...|.
Zfish   280 LMMKAVKEGGDEKLEKSWGFRFFRSPVEVLAGVDGKKAAGVRLALNKLEGEGEGARSVPTGQLED 344

  Fly   325 LPSHLILRSIGYKSSCVDTGINFDTRRGRVHNINGRILKDDATGEVDPGLYVAGWLGTGPTGVIV 389
            :...||:.||||||..::..:.||.|:..|.|..||:  .||     .|||.:||:..||||||.
Zfish   345 VDCGLIISSIGYKSLPIEPTVPFDPRKAIVPNDMGRV--QDA-----EGLYCSGWVKRGPTGVIA 402

  Fly   390 TTMNGAFAVAKTICDDINTNALDTSSVKPGYDA-------DGKRVVTWDGWQRINDFESAAGKAK 447
            ||||.:|..|:.|..|:.|..||.|..|||.:|       .|.|:|.:..|::||..|...|||.
Zfish   403 TTMNDSFDTARVIIQDMETGKLDVSVNKPGAEAITGLLQTRGVRMVLFSEWEKINAEEERRGKAL 467

  Fly   448 GKPREKIVSIEEMLRVA 464
            ||||||::.:|:||::|
Zfish   468 GKPREKLLDVEKMLKIA 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dare	NP_477150.1	PLN02852	10..465	CDD:215457	232/472 (49%)
dare	NP_477150.1	NAD_binding_8	34..98	CDD:290186	47/63 (75%)
fdxr	XP_003199702.2	PLN02852	17..484	CDD:215457	231/470 (49%)
fdxr	XP_003199702.2	NAD_binding_8	43..>88	CDD:290186	31/44 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595437
Domainoid	1	1.000	215	1.000	Domainoid score	I2672
eggNOG	1	0.900	-	-		E1_COG0493
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3033
Inparanoid	1	1.050	418	1.000	Inparanoid score	I1783
OMA	1	1.010	-	-		QHG63565
OrthoDB	1	1.010	-	-		D1324510at2759
OrthoFinder	1	1.000	-	-		FOG0004755
OrthoInspector	1	1.000	-	-		oto40864
orthoMCL	1	0.900	-	-		OOG6_101920
Panther	1	1.100	-	-	LDO	PTHR11938
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R27
SonicParanoid	1	1.000	-	-		X3346
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800