DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18335 and FAM166B

DIOPT Version :9

Sequence 1:	NP_610666.1	Gene:	CG18335 / 36202	FlyBaseID:	FBgn0033610	Length:	323	Species:	Drosophila melanogaster
Sequence 2:	NP_001274168.1	Gene:	FAM166B / 730112	HGNCID:	34242	Length:	306	Species:	Homo sapiens

Alignment Length:	323	Identity:	74/323 - (22%)
Similarity:	112/323 - (34%)	Gaps:	101/323 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ITPE-PHLVPGYTGHCAQNRDRVGRTYGRQTHKLLIDPCIYHAPELIVAPIHAKRGL-------- 60
            :.|: ||.:|||||||...|..||:|||:.|.:||..|     |.|...|:|  |.|
Human    11 LNPQNPHYIPGYTGHCPLLRFSVGQTYGQVTGQLLRGP-----PGLAWPPVH--RTLLPPIRPPR 68

  Fly    61 -KDYPTEQELKILRTREGLVDSVYRHPILPGYAGFVPNKVSQIGKRYVAAASAGVARHETLMELY 124
             .:.|.| .|.:.|.:|.|..|     ::|||.||||.      .:::.|.:......|.|.:..
Human    69 SPEVPRE-SLPVRRGQERLSSS-----MIPGYTGFVPR------AQFIFAKNCSQVWAEALSDFT 121

  Fly   125 RCENRTLRHRDLLESGNGLFDRKINERLLPQTYYRSPLILVTGVSKGIKDETCPPKTEKLCYSKF 189
            ....:. ...:|.:...|..|.:.::...|:.....|.:.|.                     :.
Human   122 HLHEKQ-GSEELPKEAKGRKDTEKDQVPEPEGQLEEPTLEVV---------------------EQ 164

  Fly   190 TSPHFLEDEDADKFIINGYSGHIPMSVTRFGESNKVLTNRALCSFSDYMYKRKRDTWCCGQDLSR 254
            .||:.::|.|..||.::.:                      |||
Human   165 ASPYSMDDRDPRKFFMSAF----------------------LCS--------------------- 186

  Fly   255 PSITCPPVGHFVVYHEDSGMVPNYAGHVPGETYK---FGRTYAKTTYDAKRWLEVHKNLTVLP 314
            |:..|..:|...  |:.....||.:.|.|..|.:   |..|...|.......|..|  |.:.|
Human   187 PTRHCRNLGRST--HQAVPRTPNISPHFPEHTLRTWVFYLTMGATCQGISSSLATH--LAISP 245

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18335	NP_610666.1	DUF2475	8..>41	CDD:287584	18/33 (55%)
CG18335	NP_610666.1	DUF2475	271..>297	CDD:287584	7/28 (25%)
FAM166B	NP_001274168.1	DUF2475	16..72	CDD:287584	25/62 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	62..84		4/22 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	125..169		8/65 (12%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	47	1.000	Domainoid score	I12101
eggNOG	1	0.900	-	-		E1_29KHB
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	103	1.000	Inparanoid score	I4965
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52846
OrthoDB	1	1.010	-	-		D497432at33208
OrthoFinder	1	1.000	-	-		FOG0008107
OrthoInspector	1	1.000	-	-		oto90255
orthoMCL	1	0.900	-	-		OOG6_109205
Panther	1	1.100	-	-	LDO	PTHR22146
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6047
SonicParanoid	1	1.000	-	-		X7065
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.870