DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18335 and Fam166b

DIOPT Version :9

Sequence 1:	NP_610666.1	Gene:	CG18335 / 36202	FlyBaseID:	FBgn0033610	Length:	323	Species:	Drosophila melanogaster
Sequence 2:	NP_796351.2	Gene:	Fam166b / 329831	MGIID:	2445194	Length:	379	Species:	Mus musculus

Alignment Length:	311	Identity:	75/311 - (24%)
Similarity:	119/311 - (38%)	Gaps:	84/311 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 PHLVPGYTGHCAQNRDRVGRTYGRQTHKLLIDPCIYHAPEL--------IVAPIHAKRGLKDYP- 64
            ||.:|||||||...|..:|:|||:.|.:||..|     |.|        ::.||.:.|.    |
Mouse    16 PHYIPGYTGHCPLLRFSMGQTYGQVTGQLLRGP-----PGLAWPPAHRTLLPPIQSPRS----PV 71

  Fly    65 -TEQELKILRTREGLVDSVYRHPILPGYAGFVPNKVSQIGKRYVAAASAGVARHETLMELYRCEN 128
             ::..|...|..|.|..|     |:|||.||:|.      .:::.|.:......|.:.|..|...
Mouse    72 ISKGRLPPRRGHERLSSS-----IIPGYTGFIPR------AQFIFAKNCNQVWAEAMSEFTRRHG 125

  Fly   129 RTLRHRDLLESGNGLFDRKINERLLPQTYYRSPLILVTGVSKGIKDETCPPKTEKLCYSKFTSPH 193
            ....|: |.:...|  :|::.|..|                   ::...||..::|.::   ||:
Mouse   126 EQESHQ-LPDGAKG--EREVEEDQL-------------------REAEEPPLKQELAHA---SPY 165

  Fly   194 FLEDEDADKFIINGYSGHIPMSVTRFGESNKVLT--------NRALCSFSDYMYKRKRDTWCCGQ 250
            .::|.|..||.::|....:  :....|....|||        :||:|...             ..
Mouse   166 SMDDTDPHKFFMSGERKWV--ATKGEGRPQDVLTQHLPHPQVSRAMCPVP-------------AS 215

  Fly   251 DLSRPSITCPPVGHF-----VVYHEDSGMVPNYAGHVPGETYKFGRTYAKT 296
            .|: |:..|.|..|.     ..:.......||.:.|.||..::...:|..|
Mouse   216 SLA-PASLCLPTRHCRNLGRCAHGAGRTRTPNLSPHFPGPRFRIWVSYLTT 265

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18335	NP_610666.1	DUF2475	8..>41	CDD:287584	17/31 (55%)
CG18335	NP_610666.1	DUF2475	271..>297	CDD:287584	7/26 (27%)
Fam166b	NP_796351.2	DUF2475	16..>85	CDD:371169	26/77 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	52	1.000	Domainoid score	I11449
eggNOG	1	0.900	-	-		E1_29KHB
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I4984
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52846
OrthoDB	1	1.010	-	-		D497432at33208
OrthoFinder	1	1.000	-	-		FOG0008107
OrthoInspector	1	1.000	-	-		oto93834
orthoMCL	1	0.900	-	-		OOG6_109205
Panther	1	1.100	-	-	LDO	PTHR22146
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6047
SonicParanoid	1	1.000	-	-		X7065
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.870