Protein Alignment CG9062 and WDR48

DIOPT Version :10

• Sequence 1: NP_001260886.1
• Gene: CG9062 / 36199
• FlyBaseID: FBgn0033607
• Length: 680
• Species: Drosophila melanogaster
• Sequence 2: NP_001333154.1
• Gene: WDR48 / 57599
• HGNCID: 30914
• Length: 715
• Species: Homo sapiens
• Alignment Length: 729
• Identity: 387/729 - (53%)
• Similarity: 488/729 - (66%)
• Gaps: 85/729 - (11%)

  Fly     1 MLTH--KTCQARKKMQVSFVIRDAEEKQHRNGVNALQLDANNGKLYSAGRDAIIRVWNTRTDSSE 63
            |..|  :....|:|:|||:||||..||.:||||||||||....:|::||||:|||:|:......:
Human     1 MAAHHRQNTAGRRKVQVSYVIRDEVEKYNRNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQD 65

  Fly    64 KYIQSMEHHNDWVNDIVLCCNGRNLISASCDTTVKVWNAQKGFCMSTLRTHRDYVQALAYAKDRE 128
            .||.|||||.||||||||||||:.|||||.|||||||||.|||||||||||:|||:|||||||:|
Human    66 PYIASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKE 130

  Fly   129 QVASAGLDKAIFLWDVNTLTALTASNNTVTT---------------------------------- 159
            .|||||||:.||||||||||||||||||||:
Human   131 LVASAGLDRQIFLWDVNTLTALTASNNTVTSLHRESVSYFESASTYSVLAPKSMIEQQRASSSLQ 195

  Fly   160 ----SSLTGSKDSIYSLAMNPSGTVIVSGSTENILRIWDPRTCMRRMKLRGHTENVRCLVVSPDG 220
                |||:|:||||||||||..||:|||||||.:||:||||||.:.|||:|||:||:.|:::.||
Human   196 SKNASSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDG 260

  Fly   221 NQVVSGSSDGTIKVWNLGQQRCVQTIHVHKEGVWSLLMSENFQYIISGSRDRNIIVTEMRNPSNK 285
            .|.:||||||||::|:||||||:.|..||.||||:|.:::.|.::.||.|||.|..|::|||..:
Human   261 TQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKIYCTDLRNPDIR 325

  Fly   286 TLVCEEQAPVLSLGYNIDKT-----GVWATTWNSDIRCWKLPMYDRCTLNSSGGMDAQWTQGGTE 345
            .|:|||:||||.:  .:|::     .:|..|..|.:..|.|....  ...:||..|...|...|.
Human   326 VLICEEKAPVLKM--ELDRSADPPPAIWVATTKSTVNKWTLKGIH--NFRASGDYDNDCTNPITP 386

  Fly   346 VA-----CIKGGAAIKECAVLNDKRYIITKDSQDQVVVYDVLRVVKKEQLGAVDFEAEVKKRNKQ 405
            :.     .|||||:|.:|.:|||||:|:|||:.:.|..:|||:..|.|.||.||||.|:|||.|.
Human   387 LCTQPDQVIKGGASIIQCHILNDKRHILTKDTNNNVAYWDVLKACKVEDLGKVDFEDEIKKRFKM 451

  Fly   406 VYIPNWFTVDLKTGMPTIVLGQEEVDCFSAWVSI-EAGL--PECVDPTTEIKINYGKLLLEALLE 467
            ||:||||:|||||||.||.|  :|.|||:||||. :||.  |:..||    |:|.|.|||:||||
Human   452 VYVPNWFSVDLKTGMLTITL--DESDCFAAWVSAKDAGFSSPDGSDP----KLNLGGLLLQALLE 510

  Fly   468 YWTPPHSIPPNEMEPDMH------------GNGYFQVPKHTPVIFSEVGGRTVCRLLVRDAAGDS 520
            ||...|..|.:|.|.:::            ||||||||.||||||.|.||||:.|||.||:.|::
Human   511 YWPRTHVNPMDEEENEVNHVNGEQENRVQKGNGYFQVPPHTPVIFGEAGGRTLFRLLCRDSGGET 575

  Fly   521 ESTLLHETAPQWVTDVVIEKNIPKFLKIPFFLQPHPQMTKPERTKKDRLVANEFIQCRKVCEHVL 585
            ||.||:||.||||.|:.::||:|||.||||:||||.. :..:..|||||.|::.:|.|||.|||.
Human   576 ESMLLNETVPQWVIDITVDKNMPKFNKIPFYLQPHAS-SGAKTLKKDRLSASDMLQVRKVMEHVY 639

  Fly   586 EKVLN----AETTPSGGNANNSLQNSQSDANSEGSQLPAEERIELWCNDVVVDPNMDLRTVRHFI 646
            ||::|    ::||.|..|.....|..:.|.     .:.|||:|||.|.|.|:|||||||||:|||
Human   640 EKIINLDNESQTTSSSNNEKPGEQEKEEDI-----AVLAEEKIELLCQDQVLDPNMDLRTVKHFI 699

  Fly   647 WKQSTDLTFQYKTK 660
            ||...|||..|:.|
Human   700 WKSGGDLTLHYRQK 713

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG9062	NP_001260886.1	WD40	27..320	CDD:238121	190/335 (57%)
		WD40 repeat	77..113	CDD:293791	31/35 (89%)
		WD40 repeat	118..158	CDD:293791	34/39 (87%)
		WD40 repeat	170..205	CDD:293791	25/34 (74%)
		WD40 repeat	211..247	CDD:293791	21/35 (60%)
		WD40 repeat	253..288	CDD:293791	14/34 (41%)
		WD40 repeat	295..319	CDD:293791	6/28 (21%)
		DUF3337	492..658	CDD:463358	91/169 (54%)
WDR48	NP_001333154.1	WD40	30..324	CDD:238121	178/293 (61%)
		WD40 repeat	35..73	CDD:293791	18/37 (49%)
		WD40 repeat	79..115	CDD:293791	31/35 (89%)
		WD40 repeat	120..156	CDD:293791	30/35 (86%)
		WD40 repeat	167..203	CDD:293791	2/35 (6%)
		WD40 repeat	210..245	CDD:293791	25/34 (74%)
		WD40 repeat	251..287	CDD:293791	21/35 (60%)
		WD40 repeat	293..328	CDD:293791	14/34 (41%)
		WD40 repeat	335..362	CDD:293791	6/28 (21%)
		WD40 repeat	401..427	CDD:293791	12/25 (48%)
		DUF3337	547..711	CDD:463358	91/169 (54%)