DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13223 and SLC24A1

DIOPT Version :9

Sequence 1:	NP_610656.1	Gene:	CG13223 / 36190	FlyBaseID:	FBgn0033599	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_004718.1	Gene:	SLC24A1 / 9187	HGNCID:	10975	Length:	1099	Species:	Homo sapiens

Alignment Length:	692	Identity:	113/692 - (16%)
Similarity:	216/692 - (31%)	Gaps:	268/692 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 WSVLGMFLITIYVFWMMQITIKNYFCPTLMVIADLLRMNESTAGVTVLAIANGSPDFFTA-IASR 110
            |.||.:|.: :|||..:.|....||.|.|.||.|.|:::|..||.|.:|....:|:.||: |...
Human   454 WVVLHVFGM-MYVFVALAIVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVF 517

  Fly   111 VQTSKHSFLSCMSQAMFLHIFVAGLVIL--TKPFNMRANTYLRDFGFLFLNTV-----YMDYIHK 168
            :..|.....:.:..|:|..:||.|...|  .:..|:......||..|..|:.:     ::|.:
Human   518 ISHSNVGIGTIVGSAVFNILFVIGTCSLFSREILNLTWWPLFRDVSFYILDLIMLILFFLDSL-- 580

  Fly   169 RPKGISWLAALPSAFIFVGYVVVAIVDQHL-----------LIARIQKMEQRQLNVAEALQLEEL 222
                |:|..:|.....:..||.....::|:           .:|::..:|........|:.::||
Human   581 ----IAWWESLLLLLAYAFYVFTMKWNKHIEVWVKEQLSRRPVAKVMALEDLSKPGDGAIAVDEL 641

  Fly   223 KPQKEMPLKRQEIDRPS-IGHGSRNKRIFRQFWNTVAEFDKDRFHRGTFLVKLYLIVKQPIDMLL 286
            :..|::.|       || :..||.:..:                |..|....:|.::...:|.|.
Human   642 QDNKKLKL-------PSLLTRGSSSTSL----------------HNSTIRSTIYQLMLHSLDPLR 683

  Fly   287 RILI----------------------PKVDMEAPQYGWSKLLFNIQVVLVPTYIAYI-------- 321
            .:.:                      .|.:.|.|    :||   ..|.:.|..:..|
Human   684 EVRLAKEKEEESLNQGARAQPQAKAESKPEEEEP----AKL---PAVTVTPAPVPDIKGDQKENP 741

  Fly   322 -----IVRGYSIAGL-------------------------------------------------- 331
                 :....|...:
Human   742 GGQEDVAEAESTGEMPGEEGETAGEGETEEKSGGETQPEGEGETETQGKGEECEDENEAEGKGDN 806

  Fly   332 ----------------------------------------------------------------- 331

Human   807 EGEDEGEIHAEDGEMKGNEGETESQELSAENHGEAKNDEKGVEDGGGSDGGDSEEEEEEEEEQEE 871

  Fly   332 -------------------------------------AVYMIALILMIPVATLIFFLTRTDTPPI 359
                                                 |:|:..|.::.|:...:..:.|.::..
Human   872 EEEEEEQEEEEEEEEEEEEKGNEEPLSLDWPETRQKQAIYLFLLPIVFPLWLTVPDVRRQESRK- 935

  Fly   360 FFRFTSGVGFMAAVFLIFCLTTEVNAMF--------FTMATILQVSQEFSLATAICWALSSNDLV 416
            ||.||    |:.::..|        |||        ..:...:.:|:|....|.:....|..||:
Human   936 FFVFT----FLGSIMWI--------AMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLI 988

  Fly   417 ANLSLAHQGWPRMAMTATFSAPVFASFVFLALPLVVNSFVNAPGNI-FPTEGGFGETVCIFLEVG 480
            .::.:|.:|...||::::..:.:|...|.|.:|.::.|.:|....: ..:.|.|...|.:||.
Human   989 TSVIVARKGLGDMAVSSSVGSNIFDITVGLPVPWLLFSLINGLQPVPVSSNGLFCAIVLLFLM-- 1051

  Fly   481 MGFSMLSVLTTNFKLRRACGFLLVSYYIFFVGVLILLEKGVI 522
            :.|.:.|:.:..:::.:..||.:...|..|:.:.::||..:|
Human  1052 LLFVISSIASCKWRMNKILGFTMFLLYFVFLIISVMLEDRII 1093

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13223	NP_610656.1	Na_Ca_ex	45..194	CDD:279963	43/154 (28%)
CG13223	NP_610656.1	Na_Ca_ex	365..516	CDD:279963	32/159 (20%)
SLC24A1	NP_004718.1	2A1904	1..1099	CDD:273344	113/692 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	123..150
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	169..199
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	284..304
		Alpha-1	494..534		10/39 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	690..901		9/217 (4%)
		Alpha-2	979..1010		7/30 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0530
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810