Protein Alignment CG13223 and ECM27

DIOPT Version :9

• Sequence 1: NP_610656.1
• Gene: CG13223 / 36190
• FlyBaseID: FBgn0033599
• Length: 527
• Species: Drosophila melanogaster
• Sequence 2: NP_012640.4
• Gene: ECM27 / 853570
• SGDID: S000003867
• Length: 725
• Species: Saccharomyces cerevisiae
• Alignment Length: 682
• Identity: 115/682 - (16%)
• Similarity: 215/682 - (31%)
• Gaps: 251/682 - (36%)

  Fly    57 IYVFWMMQITIKNYFCPTLMVIAD--LLRMNESTAGVT-------------VLAIANGSPDFFTA 106
            |..|.::.|...::.||.:..|:|  .||.|.|....|             :|:..|.|||.|:.
Yeast    32 IIAFVLLGICASDFLCPNVAHISDPNSLRSNGSLVSKTASHASHTGALMAVLLSWCNSSPDLFSN 96

  Fly   107 IASRVQTSKHSFLSCMSQAMFLHIFVAGLVILT---KPFNMRANTY-----------LRDFGFLF 157
            :.|...:::.:..:.:|.::...:...|:::..   ..|.:.:.|:           :||..|..
Yeast    97 LMSWATSTRETRSTSVSLSIGEVLGACGIILCIVEGSIFIIMSRTHIEISQIQKLSIMRDLLFSL 161

  Fly   158 LNTVYMDYIHKRPKGISWLAALPSAFIFVGYVVVAI----------------------------V 194
            .....|.|:....: ::.|..|..||::..|:||.:                            :
Yeast   162 AAMCVMSYVSLMNQ-VTVLNCLLMAFLYAFYLVVKLTFKLNHSAETPDETAADTSLRENSVSPFL 225

  Fly   195 DQHLLIARIQKMEQRQLNVAEAL------------------------QLEELKPQKEM------- 228
            |..|:.:.:....|...:::.::                        .|||...:.||
Yeast   226 DDSLMASGLLPPIQPGFDISNSITHGIKPSLLSAMDFNSFLSMLENSSLEEDDSRNEMAELNTLR 290

  Fly   229 ---PLKRQEIDRPSIGHGSRNKRIFRQFWNTVAEF-DKDRF------------------------ 265
               |.:.........|..:...|.|.:..|...|: |.:|.
Yeast   291 SMTPGQHWSASATVAGEATSAGRPFSEPTNAFTEYRDSERAINSSPAVFAPYRDNPDDEESQEQV 355

  Fly   266 --------HRGT------------FLVKLYL-----------------IVKQPIDMLLRILIPK- 292
                    |.|.            :::|:::                 |:..|..::.::..|:
Yeast   356 LLETTTHGHFGAQEMRRFSKRSLGWIIKIFIPHLSNFSQKSISDAIFSIITVPFFIIFKLSCPQP 420

  Fly   293 ------VDMEAPQYGWSKL---LFNIQVVLVPTYIAYI--IVRGYSIAGLAVYMIALIL-MIPVA 345
                  .|....:|..:.|   |..||.:..|..:..|  ::..|.: |..||:..||| |..:.
Yeast   421 PSDILSYDPTLNRYSLTTLPIILLFIQSITAPFLLCSILSVLLTYHL-GYLVYLFPLILAMALIL 484

  Fly   346 TLIFFLTRTDTPPIFFRFT------------------------------SGVGFMAAVFLIFCLT 380
            .|..|:|:.:   :..:||                              ..:|.:..:..|..|.
Yeast   485 LLTAFITKVN---LHNKFTLSLDSSNILQEKLQKRKLLERLNTSIQIIFLAIGIINIIIWISLLA 546

  Fly   381 TEVNAMFFTMATILQVSQEFSLATAICWALSSNDLVANLSLAHQGWPRMAMTATFSAPVFASFVF 445
            ..:..|......||.:|:.....|...|..|..||::|:|:.     |:..|.|.    :...|.
Yeast   547 NSLIEMMEIYQKILGLSKAILGLTIFAWGNSVGDLISNISMC-----RLYKTQTH----YQDRVR 602

  Fly   446 LALPLVVNSFVNAPGNIFPTEGGFGETVCIFLEVGMGFS-MLSVL-------------------- 489
            ||....:.|..:..|.:.....|           |:||| ::|:|
Yeast   603 LATKFFMISCASCLGGVMLNSMG-----------GIGFSGLVSMLFIGAFNDNEWWFLRKVKLQE 656

  Fly   490 ------TTNFKLRRACGFL---LVSYYIFFVG 512
                  |.|:|...:|.|:   ::...:||.|
Yeast   657 TSQLDNTLNYKFIVSCVFIILQIILLLLFFGG 688

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG13223	NP_610656.1	Na_Ca_ex	45..194	CDD:279963	35/193 (18%)
		Na_Ca_ex	365..516	CDD:279963	37/178 (21%)
ECM27	NP_012640.4	ECM27	18..>225	CDD:223604	35/193 (18%)
		PLN03151	<544..637	CDD:215604	26/112 (23%)
		ECM27	<558..721	CDD:223604	33/151 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344060
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0530
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4675
OMA	1	1.010	-	-		QHG57812
OrthoFinder	1	1.000	-	-		FOG0000933
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101277
Panther	1	1.100	-	-	O	PTHR12266
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1775
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.730