DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13223 and SLC8B1

DIOPT Version :9

Sequence 1:	NP_610656.1	Gene:	CG13223 / 36190	FlyBaseID:	FBgn0033599	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_001345274.1	Gene:	SLC8B1 / 80024	HGNCID:	26175	Length:	584	Species:	Homo sapiens

Alignment Length:	543	Identity:	140/543 - (25%)
Similarity:	247/543 - (45%)	Gaps:	51/543 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SQKCKFVQTTPDCLINMNLFNYLGWHYCKVDVRNSFNSFWSVLGMFLITIYVFWMMQ------IT 66
            |.:|.|::|.|||..:....:||...:|         .|...|....:|:||.|::.      :|
Human    62 SDRCDFIRTNPDCHSDGGYLDYLEGIFC---------HFPPSLLPLAVTLYVSWLLYLFLILGVT 117

  Fly    67 IKNYFCPTLMVIADLLRMNESTAGVTVLAIANGSPDFFTAIA--SRVQTSKHSFLSCMSQAMFLH 129
            ...:|||.|..|:..|:::.:.||||.||..||:||.|:|:.  |...|:..:..:.....:.:.
Human   118 AAKFFCPNLSAISTTLKLSHNVAGVTFLAFGNGAPDIFSALVAFSDPHTAGLALGALFGAGVLVT 182

  Fly   130 IFVAGLVILTKPFNMRANTYLRDFGFLFLNTVYMDY--IHKRPKGISWLAALPSAFIFVGYVVVA 192
            ..|||.:.:..||...:..:.||..| ::..|::.:  :.:....::|  ||....::|.|||..
Human   183 TVVAGGITILHPFMAASRPFFRDIVF-YMVAVFLTFLMLFRGRVTLAW--ALGYLGLYVFYVVTV 244

  Fly   193 IVDQHLLIARIQKMEQRQLNVAEALQLEELKPQKEMPLKRQEIDRPSIGHGSRNKRIFRQFWNTV 257
            |:...:    .|:..:..|.....:..|.|...:|   .|...:..|..:|...:.:| .:..|.
Human   245 ILCTWI----YQRQRRGSLFCPMPVTPEILSDSEE---DRVSSNTNSYDYGDEYRPLF-FYQETT 301

  Fly   258 AE--------FDKDRFHRGTFLVKLYLIVKQPIDMLLRILIPKVDMEAPQYGWSKLLFNIQVVLV 314
            |:        .|..::.|.:...|...:.|.|::.||.:.:|.||.:.....|.:.|..:.:|:.
Human   302 AQILVRALNPLDYMKWRRKSAYWKALKVFKLPVEFLLLLTVPVVDPDKDDQNWKRPLNCLHLVIS 366

  Fly   315 PTYIAYIIVRG----YSIAGLA-VYMIALILMIPVATLIFFLTRTDTPPIFFRFTSGVGFMAAVF 374
            |..:...:..|    |.|.||. |:::.:|....:|::.||.|....||......:.:||:.:..
Human   367 PLVVVLTLQSGTYGVYEIGGLVPVWVVVVIAGTALASVTFFATSDSQPPRLHWLFAFLGFLTSAL 431

  Fly   375 LIFCLTTEVNAMFFTMATILQVSQEFSLATAICWALSSNDLVANLSLAHQGWPRMAMTATFSAPV 439
            .|....|||..:..::..:.::|......|.:.|..|..|..::.:||.||:||||.:|.|...:
Human   432 WINAAATEVVNILRSLGVVFRLSNTVLGLTLLAWGNSIGDAFSDFTLARQGYPRMAFSACFGGII 496

  Fly   440 FASFVFLALPLVVN-SFVNAPGNIFPTEGGFGETVCIF---LEVGMGFSMLSVLTTNFKLRRACG 500
            |...|.:.|..::. |..:....:.|.    |..|.:.   |.:.:.||::||....|:|.|..|
Human   497 FNILVGVGLGCLLQISRSHTEVKLEPD----GLLVWVLAGALGLSLVFSLVSVPLQCFQLSRVYG 557

  Fly   501 FLLVSYYIFFVGVLILLEKGVIH 523
            |.|:.:|:.|:.|.:|.|.||||
Human   558 FCLLLFYLNFLVVALLTEFGVIH 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13223	NP_610656.1	Na_Ca_ex	45..194	CDD:279963	43/158 (27%)
CG13223	NP_610656.1	Na_Ca_ex	365..516	CDD:279963	42/154 (27%)
SLC8B1	NP_001345274.1	Na_Ca_ex	63..584	CDD:332332	139/542 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147886
Domainoid	1	1.000	66	1.000	Domainoid score	I9954
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57812
OrthoDB	1	1.010	-	-		D257493at33208
OrthoFinder	1	1.000	-	-		FOG0000933
OrthoInspector	1	1.000	-	-		otm40494
orthoMCL	1	0.900	-	-		OOG6_101277
Panther	1	1.100	-	-	O	PTHR12266
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1775
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.890