DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13223 and slc24a2

DIOPT Version :9

Sequence 1:	NP_610656.1	Gene:	CG13223 / 36190	FlyBaseID:	FBgn0033599	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	XP_017211234.1	Gene:	slc24a2 / 751686	ZFINID:	ZDB-GENE-060825-277	Length:	628	Species:	Danio rerio

Alignment Length:	532	Identity:	107/532 - (20%)
Similarity:	206/532 - (38%)	Gaps:	100/532 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 VLGMFLITIYVFWMMQITIKNYFCPTLMVIADLLRMNESTAGVTVLAIANGSPDFFTA-IASRVQ 112
            ||.||.: :|:|..:.|....:|.|.|.||.:.|.:::..||.|.:|....:|:.||: |...:.
Zfish   133 VLHMFGM-MYMFIALAIVCDEFFVPALTVITEKLEISDDVAGATFMAAGGSAPELFTSVIGVFIS 196

  Fly   113 TSKHSFLSCMSQAMFLHIFVAGLVIL--TKPFNMRANTYLRDFGFLFLNTV---------YMDYI 166
            .|.....:.:..|:|..:||.|:..|  .:..|:......||..|..:..:         |:.|:
Zfish   197 HSNVGIGTIVGSAVFNILFVIGMCALFSREILNLTWWPLFRDVSFYIIGLIMLIVFFLDNYITYV 261

  Fly   167 HKRPKGISWLAALPSAFIFVGY--VVVAIVDQHLLIARIQKMEQRQLNVAEALQLEELKPQKEMP 229
                :..:.|:...|...|:.:  .|...:...||..::..:|.....|:        .|..|..
Zfish   262 ----ESFALLSCYGSYVTFMKFNSSVETWIKTRLLGNQVDDIEAPPKVVS--------VPDDENK 314

  Fly   230 LKRQEIDRPSIGHGS----------RNKRIFRQFWNTVAEFDKDRFHRGTFLVKLYLIVKQPIDM 284
            |..    :|.:..|.          ||. ||:...:|:....:.:|             |:...:
Zfish   315 LSA----KPRLQRGGSSASLHNTLMRNS-IFQLMIHTLDPLSEGKF-------------KEKASI 361

  Fly   285 LLRILIPKVDMEA--PQYGWSKLLF---------NIQVVLVPTY--------------------- 317
            |.:|...|...||  .:.|..|.:.         |::|.:.|..
Zfish   362 LHKIARKKGQDEANGVEDGQRKCMLMDKNLPNSSNVEVEVTPPMNGSAGPEVEVEEEEEDEDQPL 426

  Fly   318 -IAYIIVRGYSIAGLAVYMIALILMIPVATLIFFLTRTDTPPIFFRFTSGVGFMAAVFLIFCLTT 381
             :|:.......:..|.::.|...|.:.:..:....:|...|..|....|.:.|.:  :|:.....
Zfish   427 SLAWPDTIRKQVTYLFIFPIVFPLWLSLPDVRRESSRKFFPVTFLGSISWIAFFS--YLMVWWAH 489

  Fly   382 EVNAMFFTMATILQVSQEFSLATAICWALSSNDLVANLSLAHQGWPRMAMTATFSAPVFASFVFL 446
            :|       ...:.:::|....|.:....|..||:.::.:|.:|...||::::..:.:|...|.|
Zfish   490 QV-------GETIGITEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGL 547

  Fly   447 ALPLVVNSFVNAPGNIFPTEGG-FGETVCIFLEVGMGFSMLSVLTTNFKLRRACGFLLVSYYIFF 510
            ..|.::.|.:|...::..:..| |...|.:||.  :.|.::|:....:|:.:..|||:...|..|
Zfish   548 PFPWLLFSMLNDFSSVAVSSNGLFCAIVLLFLM--LLFVIISIAVCKWKMSKMLGFLMFLLYFVF 610

  Fly   511 VGVLILLEKGVI 522
            :.|.::||..:|
Zfish   611 LVVSVMLEDKII 622

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13223	NP_610656.1	Na_Ca_ex	45..194	CDD:279963	38/158 (24%)
CG13223	NP_610656.1	Na_Ca_ex	365..516	CDD:279963	33/151 (22%)
slc24a2	XP_017211234.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0530
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810