DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG13223 and SLC24A3

DIOPT Version :9

Sequence 1:	NP_610656.1	Gene:	CG13223 / 36190	FlyBaseID:	FBgn0033599	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_065740.2	Gene:	SLC24A3 / 57419	HGNCID:	10977	Length:	644	Species:	Homo sapiens

Alignment Length:	685	Identity:	130/685 - (18%)
Similarity:	227/685 - (33%)	Gaps:	240/685 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DLLESQKCKFVQTTPDCLIN---------MNLFNYLG----WHYCK-------------VDVRNS 42
            |||.||.| |:.:....|.:         ::|.:.:|    |...:             ..:|||
Human    21 DLLLSQLC-FLASVALLLWSLSSLREQKELDLMDLVGEDRKWMMARKLMQVNDTLTSEDAGLRNS 84

  Fly    43 FNSFWSVLGMF-------------------LITIYVFWMMQITIKNYFCPTLMVIADLLRMNEST 88
            .|.....|..|                   |..||:|:.:.|...::|.|:|..|.:.|.::|..
Human    85 KNCTEPALHEFPNDIFTNEDRRQGAVVLHVLCAIYMFYALAIVCDDFFVPSLEKICERLHLSEDV 149

  Fly    89 AGVTVLAIANGSPDFFTAIASRVQTSKHSFL-SCMSQAMFLHIFV-------AGLVILTKPFNMR 145
            ||.|.:|..:.:|:.||::.....|.....: :.:..|:|..:.:       ||.|:....:.:
Human   150 AGATFMAAGSSAPELFTSVIGVFITKGDVGVGTIVGSAVFNILCIIGVCGLFAGQVVALSSWCL- 213

  Fly   146 ANTYLRDFGFLFLNTVYMDYIHKRPKGISWLAALPSAFIFVGYVVVAIVDQHLLIARIQKMEQRQ 210
                |||..:..|:.:.: .:....:.:||..:|....:::.|:|:...:     |.|.:..:|:
Human   214 ----LRDSIYYTLSVIAL-IVFIYDEKVSWWESLVLVLMYLIYIVIMKYN-----ACIHQCFERR 268

  Fly   211 L----NVAEALQLEELKPQKEMPLKRQEIDRPSIGHGSRNKRIFRQFWN---TVAEFDKDRFHRG 268
            .    |:...|            ....|||..|               |   ||....|..|||.
Human   269 TKGAGNMVNGL------------ANNAEIDDSS---------------NCDATVVLLKKANFHRK 306

  Fly   269 TFLVKL-YLIVKQPIDML-----LRILI-----PKVDMEAPQYGWSKLLFNIQVVLVPTYIAYII 322
            ..::.: .|:...|..:.     |||:|     ||..:...    |::|.|.:..|:.:
Human   307 ASVIMVDELLSAYPHQLSFSEAGLRIMITSHFPPKTRLSMA----SRMLINERQRLINS------ 361

  Fly   323 VRGYSIAGLAVYMIALILMIPVATLIFF------------------------------------- 350
             |.|:.....|     .:.||:...:..
Human   362 -RAYTNGESEV-----AIKIPIKHTVENGTGPSSAPDRGVNGTRRDDVVAEAGNETENENEDNEN 420

  Fly   351 --------------LTRTDTP-----PIFFRFTSGVGFMAAV-------------FLI-FCLTT- 381
                          .|..|||     .:.:.||..:.|:...             |:: |..:|
Human   421 DEEEEEDEDDDEGPYTPFDTPSGKLETVKWAFTWPLSFVLYFTVPNCNKPRWEKWFMVTFASSTL 485

  Fly   382 ---EVNAMFFTMATI----LQVSQEFSLATAICWALSSNDLVANLSLAHQGWPRMAMTATFSAPV 439
               ..:.|...|.||    |.:.......|.:....|..|.:|:|.:|.||...||::.:..:.|
Human   486 WIAAFSYMMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGMGDMAVSNSIGSNV 550

  Fly   440 FASFVFLALPLVVNSF---------VNAPGNIFPTEGGFGETVCIFLEVGMGFSMLSVLTTNFKL 495
            |...:.|.||..:.:.         :|:.|.|:                .:|..:.||..|.|.:
Human   551 FDILIGLGLPWALQTLAVDYGSYIRLNSRGLIY----------------SVGLLLASVFVTVFGV 599

  Fly   496 ---------RRACGFLLVSYYIFFVGVLILLEKGV 521
                     :..||.||:  |..|:...|:.|..|
Human   600 HLNKWQLDKKLGCGCLLL--YGVFLCFSIMTEFNV 632

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13223	NP_610656.1	Na_Ca_ex	45..194	CDD:279963	35/175 (20%)
CG13223	NP_610656.1	Na_Ca_ex	365..516	CDD:279963	38/190 (20%)
SLC24A3	NP_065740.2	TIGR00367	112..605	CDD:273039	104/562 (19%)
		Na_Ca_ex	113..255	CDD:279963	33/147 (22%)
		Alpha-1	149..189		9/39 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	405..442		3/36 (8%)
		Na_Ca_ex	475..627	CDD:279963	37/169 (22%)
		Alpha-2	518..549		9/30 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0530
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1775
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840