DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG13223 and CG5348

DIOPT Version :9

Sequence 1:	NP_610656.1	Gene:	CG13223 / 36190	FlyBaseID:	FBgn0033599	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_611156.3	Gene:	CG5348 / 36877	FlyBaseID:	FBgn0034156	Length:	625	Species:	Drosophila melanogaster

Alignment Length:	587	Identity:	151/587 - (25%)
Similarity:	255/587 - (43%)	Gaps:	87/587 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 QKCKFVQTTPDCLINMNLFNYLGWHYCKVDVRNSFNSFWSVLGMFLITIYVFWMMQI------TI 67
            ::|:|||...||..:.|:..|:....|.:...|.|..      |..|.::|.:..||      ||
  Fly    43 ERCEFVQKAEDCNSSTNVIPYMRLLACDLKCINQFQE------MIFIALFVAFCFQILVLLIYTI 101

  Fly    68 KNYFCPTLMVIADLLRMNESTAGVTVLAIANGSPDFFTAIASRVQTSKHSFLSCMSQAMFLHIFV 132
            ..|:.|.|..::..|.|||..||||::|..|.|.|||..:|| |:.....|.:.:|.|:|:....
  Fly   102 NVYYSPALKAVSRFLHMNEHLAGVTLMAFGNTSADFFANLAS-VERHVPVFANNLSSALFVITIS 165

  Fly   133 AGLVILTKPFNMRANTYLRDFGFLFLNTVYMDYIHKRPKGISWLAALPSAF-------IFVGYVV 190
            .||:....||.|.:...:||..||.|.|:.|||........    ||...|       :::.|::
  Fly   166 GGLIFYISPFKMNSYETVRDILFLLLATLLMDYFAYTTNHF----ALGYEFKFFIVLLVYISYII 226

  Fly   191 VAIVDQHLL---IA----RIQKMEQRQLNVAEALQLEELKPQKEMPLKRQEID------------ 236
            :.:.|.:||   ||    ::||:...:.....||:|::|:.:.|...:...::
  Fly   227 INVADVYLLQKTIASTRTKMQKLLDEKQTPEIALKLQDLERKLEYYSQDTRVEILEKSSSISITR 291

  Fly   237 ------------RPSIGH-----------GSRNKRIFRQFWNTVAEFDKDRFHRGTFLVKLYLIV 278
                        |.|:..           .|:|:.|||.|:..:.......:.:...|.::.|::
  Fly   292 IRYTTMRMIRNPRVSVNRRYTRNMKLDYTQSKNQGIFRDFFLALRPIKCQAWKQAELLNRVLLLI 356

  Fly   279 KQPIDMLLRILIPKVDMEAPQYGWSKLLFNIQVVLVP---------------TYIAYIIVRGYSI 328
            :.|..::..:.||.||.|..::||:|||..|.||:.|               .::.||.::...|
  Fly   357 RAPAVVICTLYIPLVDYEMEKHGWNKLLNAINVVVNPALSISIFLSFMHRKGNFLWYISLQNTLI 421

  Fly   329 AGLAVYMIALILMIPVATLIFFLTRTDTPPIFFRFTSGVGFMAAVFLIFCLTTEVNAMFFTMATI 393
            .|.:    :.:|.:|.|..|.|..|||.||.:....:.:....::||||...||::.:...:..|
  Fly   422 YGAS----SFVLTVPFAVFILFHARTDVPPSYHWVFTIMNLTGSMFLIFLCATEIDTVLEVIGNI 482

  Fly   394 LQVSQEFSLATAICWALSSNDLVANLSLAHQGWPRMAMTATFSAPVFASFVFLALPLVVNSFVNA 458
            |.:...:..||...:..:...|.||.::|..|:|:||..:......|...|.......|.|.|..
  Fly   483 LSIDDNYMGATVKAFTGNLGTLFANTAVAIHGYPKMAFASAIGGSFFTIVVTGNTVAYVRSLVGN 547

  Fly   459 PGNIFPTEGGFGETVCIFLEVGMGFSMLSVLTTNFKLRRACGFLLVSYYIFFVGVLILLEKGVIH 523
            .......|  :||...|||.:.:...:|...|..|..||:.|...:..|:.::..:.|:.:.|||
  Fly   548 RSEHHMEE--YGEIAFIFLNMALFTILLWSTTLGFFARRSMGLYSIGLYVVYLLFVTLVHEEVIH 610

  Fly   524 AY 525
            ::
  Fly   611 SF 612

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13223	NP_610656.1	Na_Ca_ex	45..194	CDD:279963	49/161 (30%)
CG13223	NP_610656.1	Na_Ca_ex	365..516	CDD:279963	36/150 (24%)
CG5348	NP_611156.3	Na_Ca_ex	86..>186	CDD:279963	35/100 (35%)
CG5348	NP_611156.3	Na_Ca_ex	458..603	CDD:279963	36/146 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45450104
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0530
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	131	1.000	Inparanoid score	I1872
Isobase	1	0.950	-	0	Normalized mean entropy	S4675
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D257493at33208
OrthoFinder	1	1.000	-	-		FOG0000933
OrthoInspector	1	1.000	-	-		otm26516
orthoMCL	1	0.900	-	-		OOG6_101277
Panther	1	1.100	-	-	P	PTHR12266
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	10	9.750