DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG13223 and CG14743

DIOPT Version :9

Sequence 1:	NP_610656.1	Gene:	CG13223 / 36190	FlyBaseID:	FBgn0033599	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_610408.2	Gene:	CG14743 / 35860	FlyBaseID:	FBgn0033326	Length:	611	Species:	Drosophila melanogaster

Alignment Length:	567	Identity:	131/567 - (23%)
Similarity:	247/567 - (43%)	Gaps:	53/567 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 KCKFVQTTPDCLINMNLFNYLGWHYCKVDVRNSFNSFWSVLGMFLITIYVFWMMQITIKNYFCPT 74
            :|:......||....|.|||....||...:.|.......:|...||..:...::...:.:||.||
  Fly    37 RCEMATKIDDCKYITNFFNYYVMMYCSFKIDNKITEIVVMLLFALIYCFFLCILYEGVNSYFAPT 101

  Fly    75 LMVIADLLRMNESTAGVTVLAIANGSPDFFTAIASRVQTSKHSFLSCMSQAMFLHIFVAGLVILT 139
            |.:.|..:|:||..|||.::.:||.:||....: |.|:....:|...|:.|:.:.....|.|...
  Fly   102 LKIAALKMRINEYMAGVVLVGVANSTPDLLVNL-SPVRMEGLTFNIAMANALTIICLSGGAVCFI 165

  Fly   140 KPFNMRANTYLRDFGFLFLNTVYMDYIHKRPKGISWLAALPSAFIFVGYVVVAIVDQHLLIARIQ 204
            :||.|..::..||..||.|....:.:.........|:.......|:..|:::.|||..||...|:
  Fly   166 RPFRMNGHSIFRDLLFLLLIIELVRFFMNDTALAPWIKGAILLSIYPIYLLINIVDLILLRYAIR 230

  Fly   205 KM-------------EQRQLNVAEAL-QLEELKPQKEMPLKRQEIDR-------------PSIGH 242
            |:             .:..|.:.|.: :|..|:...|:.:...::.|             |.|.|
  Fly   231 KLRADIEVLRQSPSSREHDLILTEKIVRLNNLQQDDEIQILESKLYRKRTYNAGFFVTPKPLIHH 295

  Fly   243 G----SRNKRI------------FRQFWNTVAEFDKDRFHRGTFLVKLYLIVKQPIDMLLRILIP 291
            .    ..|:||            |.:|...:...|.:.::......::..|:|.|:.::|.:::|
  Fly   296 KEVDVETNRRILHSKANPKNLFLFSEFLQAINPIDSEGWYLSGTCARILQILKAPVTLMLHLVVP 360

  Fly   292 KVDMEAPQYGWSKLLFNIQVVLVP--------TYIAYIIVRGYSIAGLAVYMIALILMIPVATLI 348
            .||.:..::||||:|..:|:||.|        |.:.:.....|.:....:.:.:|::.:|:|.::
  Fly   361 LVDYQLVKHGWSKMLNCLQIVLTPFVIFALVETMLVHKYAEWYYVPQFRMAIWSLLVTMPLAIVV 425

  Fly   349 FFLTRTDTPPIFFRFTSGVGFMAAVFLIFCLTTEVNAMFFTMATILQVSQEFSLATAICWALSSN 413
            |..:|||.||.:......:.....:...:....|::|:...:..:..::..:...|....:.::.
  Fly   426 FLHSRTDIPPFYHSSYCALTISTVIIFFWICAWEMDALISIIGVVFDLAPSYMSITFNSVSAATA 490

  Fly   414 DLVANLSLAHQGWPRMAMTATFSAPVFASFVFLALPLVVNSFVNAPGNIFPTEGGFGETVCIFLE 478
            ||:|...||..|:.:||..|.....|::..|.:.:.||:...:|:.|.:. ..|..|.|:.|||.
  Fly   491 DLIAYAHLAKHGYGKMAFGAIIGGSVYSLAVNVGIELVLQKKLNSRGQVV-LYGDDGVTIYIFLV 554

  Fly   479 VGMGFSMLSVLTTNFKLRRACGFLLVSYYIFFVGVLILLEKGVIHAY 525
            :.:..::...||.||..||:.|..:.|.::.|:.....:|...:|.:
  Fly   555 ITITTTLWWCLTFNFVARRSAGLFMWSLFVLFLVYTTAIELQWVHGF 601

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13223	NP_610656.1	Na_Ca_ex	45..194	CDD:279963	37/148 (25%)
CG13223	NP_610656.1	Na_Ca_ex	365..516	CDD:279963	33/150 (22%)
CG14743	NP_610408.2	Na_Ca_ex	77..220	CDD:279963	37/143 (26%)
CG14743	NP_610408.2	Na_Ca_ex	450..591	CDD:279963	33/141 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45450103
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0530
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	131	1.000	Inparanoid score	I1872
Isobase	1	0.950	-	0	Normalized mean entropy	S4675
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D257493at33208
OrthoFinder	1	1.000	-	-		FOG0000933
OrthoInspector	1	1.000	-	-		otm26516
orthoMCL	1	0.900	-	-		OOG6_101277
Panther	1	1.100	-	-	P	PTHR12266
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	10	9.750