DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG13223 and CG14744

DIOPT Version :9

Sequence 1:	NP_610656.1	Gene:	CG13223 / 36190	FlyBaseID:	FBgn0033599	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_001097232.2	Gene:	CG14744 / 35858	FlyBaseID:	FBgn0033324	Length:	620	Species:	Drosophila melanogaster

Alignment Length:	595	Identity:	150/595 - (25%)
Similarity:	263/595 - (44%)	Gaps:	75/595 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 HDLLESQKCKFVQTTP------------DCLINMNLFNYLGWHYCKVDVRNSFNSFWSVLGMFLI 55
            |..:::..|:.|...|            ||...:|.|||....||.:|:.:.......:|....|
  Fly    20 HYFIKNMSCRAVMRLPYNYRCRMATQVSDCKRIINFFNYFRMMYCSIDIDDKATEVLFMLLFAFI 84

  Fly    56 TIYVFWMMQITIKNYFCPTLMVIADLLRMNESTAGVTVLAIANGSPDFFTAIASRVQTSKHSFLS 120
            .:...|:|...|..||.|.|.:|:..|.|||..||||.||..|.||:....:.. |:.....|..
  Fly    85 CVAFLWLMSFNIGTYFSPVLKIISLKLHMNEYLAGVTFLAFGNCSPEIIANLMP-VRADAPIFTI 148

  Fly   121 CMSQAMFLHIFVAGLVILTKPFNMRANTYLRDFGFLFLNTVYMDYIHKRPKGISWLAALPSAFIF 185
            .:...:.:.:...|.|...:||.|..::.|||..||.|....:.::..:...::....:....|:
  Fly   149 TVGNTLAIILLSGGTVCFLRPFRMNGHSTLRDLLFLLLGVEVLRFVMIKEGAVTLGEGIVLFLIY 213

  Fly   186 VGYVVVAIVDQHLLIARIQKMEQRQLNVAEAL----------QLEELKPQKE------------- 227
            |.||.:.|.|..||...|:|: :|:|:..|.|          ::.:|...:|
  Fly   214 VVYVAINIADLALLRYYIRKL-RRELDYLEGLTPPPITEINAKIRKLISWEEQDDIGIKDTTKYR 277

  Fly   228 ---------------------MPLKRQ-----EIDRPSIGHGS---RNKRIFRQFWNTVAEFDKD 263
                                 :|.:|.     |::|.:: |.|   :|.::|.:|:.::...|.:
  Fly   278 RSRDTGNHFSNMTSSGYFVTPIPERRSEHVDYELNRTAL-HDSENPKNLQLFTEFFQSLNPVDAE 341

  Fly   264 RFHRGTFLVKLYLIVKQPIDMLLRILIPKVDMEAPQYGWSKLLFNIQVVLVPTYIAYIIVRGYS- 327
            .:..|.:..::|||.:.|:..:|::.||.||.|..::||||||...|:|..|..:..::..|.|
  Fly   342 AWQLGGWSNRIYLIARCPLVFVLQLFIPVVDYEKIKHGWSKLLNCTQIVTNPFVVITLVHSGVSS 406

  Fly   328 -------IAGLAVYMIALILMIPVATLIFFLTRTDTPPIFFRFTSGVGFMAAVFLIFCLTTEVNA 385
                   ....::.|.:..|.:|:|.:||..:|||.||.:......:.|.:::..::...||:..
  Fly   407 VYKTWHITLDFSISMWSPCLTVPLAIVIFLHSRTDVPPSYHHLFIILTFFSSMVTLWLAVTELEV 471

  Fly   386 MFFTMATILQVSQEFSLATAICWALSSNDLVANLSLAHQGWPRMAMTATFSAPVFASFVFLALPL 450
            :...:..:..:|:.|...|....:.::.|::||..||.||:.|||..|....||||..|.::|..
  Fly   472 LSEIVGIVFNLSESFMAVTFEAVSNATPDIIANYQLALQGYGRMAFAAIIGGPVFAILVSMSLAF 536

  Fly   451 VVNSFVNAPGNIFPTEGGFGETVCIFLEVGMGFSMLSVLTTNFKLRRACGFLLVSYYIFFVGVLI 515
            :.|..|...|......|..|:...:||.:.:..:|...:|.:|..||:.|..|...|:.|:...:
  Fly   537 IFNHRVREVGANSWVYGDLGDNCYLFLVITIVTTMWWSVTFDFHARRSAGVFLWLVYLQFLLYAV 601

  Fly   516 LLEKGVIHAY 525
            .:|..|:|.:
  Fly   602 CVEWDVVHEF 611

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13223	NP_610656.1	Na_Ca_ex	45..194	CDD:279963	40/148 (27%)
CG13223	NP_610656.1	Na_Ca_ex	365..516	CDD:279963	39/150 (26%)
CG14744	NP_001097232.2	Na_Ca_ex	79..221	CDD:279963	40/142 (28%)
CG14744	NP_001097232.2	Na_Ca_ex	450..601	CDD:279963	39/150 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45450101
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0530
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	131	1.000	Inparanoid score	I1872
Isobase	1	0.950	-	0	Normalized mean entropy	S4675
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D257493at33208
OrthoFinder	1	1.000	-	-		FOG0000933
OrthoInspector	1	1.000	-	-		otm26516
orthoMCL	1	0.900	-	-		OOG6_101277
Panther	1	1.100	-	-	P	PTHR12266
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1775
SonicParanoid	0	0.000	Not matched by this tool.
	11	10.780