DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13223 and Slc8b1

DIOPT Version :9

Sequence 1:	NP_610656.1	Gene:	CG13223 / 36190	FlyBaseID:	FBgn0033599	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_573484.2	Gene:	Slc8b1 / 170756	MGIID:	2180781	Length:	585	Species:	Mus musculus

Alignment Length:	543	Identity:	145/543 - (26%)
Similarity:	247/543 - (45%)	Gaps:	50/543 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SQKCKFVQTTPDCLINMNLFNYLGWHYCKVDVRNSFNSFWSVLGMFLITIYVFWMMQ------IT 66
            |.:|.||:..|||.......:||...:|         .|...|....||:||||::.      :|
Mouse    62 SDRCDFVRRNPDCRSEAGYLDYLEGIFC---------YFPPNLLPLAITLYVFWLLYLFLILGVT 117

  Fly    67 IKNYFCPTLMVIADLLRMNESTAGVTVLAIANGSPDFFTAIA--SRVQTSKHSFLSCMSQAMFLH 129
            ...:|||.|..|:..|:::.:.||||.||..||:||.|:|:.  |..:|:..:..:.....:.:.
Mouse   118 AAKFFCPNLSAISTNLKLSHNVAGVTFLAFGNGAPDIFSALVAFSDPRTAGLAIGALFGAGVLVT 182

  Fly   130 IFVAGLVILTKPFNMRANTYLRDFG------FLFLNTVYMDYIHKRPKGISWLAALPSAFIFVGY 188
            ..|||.:.:..||...:..:|||..      ||....:|:..|     .::|  ||....::|.|
Mouse   183 TVVAGGITILHPFMAASRPFLRDIAFYMVAVFLTFTALYLGRI-----TLTW--ALGYLGLYVFY 240

  Fly   189 VVVAIVDQHLLIARIQKMEQRQL--NVAEALQLEELKPQKEMPLKRQEID-----RPSIGHGSRN 246
            ||..|:...:    .|:...|.|  :::|..:|.....:.:|.......|     ||.:......
Mouse   241 VVTVIICTWV----YQRQRSRSLVHSISETPELLSESEEDQMSSNTNSYDYGDEYRPLLLGRETT 301

  Fly   247 KRIFRQFWNTVAEFDKDRFHRGTFLVKLYLIVKQPIDMLLRILIPKVDMEAPQYGWSKLLFNIQV 311
            .:|..|..|.:   |..::...:...::..:||.|::.||.:.:|.||.:.....|.:.|..:|:
Mouse   302 VQILIQALNPL---DYRKWRTQSISWRVLKVVKLPVEFLLLLTVPVVDPDKDDRNWKRPLNCLQL 363

  Fly   312 VLVPTYIAYIIVRG----YSIAG-LAVYMIALILMIPVATLIFFLTRTDTPPIFFRFTSGVGFMA 371
            |:.|..:...:..|    |.|.| |.|:.:.:|:...:|::.||.|....||......:.:||:.
Mouse   364 VISPLVLVLTLQSGVYGIYEIGGLLPVWAVVVIVGTALASVTFFATSNREPPRLHWLFAFLGFLT 428

  Fly   372 AVFLIFCLTTEVNAMFFTMATILQVSQEFSLATAICWALSSNDLVANLSLAHQGWPRMAMTATFS 436
            :...|....|||..:..::..|.::|......|.:.|..|..|..::.:||.||:||||.:|.|.
Mouse   429 SALWINAAATEVVNILRSLGVIFRLSNTVLGLTLLAWGNSIGDAFSDFTLARQGYPRMAFSACFG 493

  Fly   437 APVFASFVFLALPLVVNSFVNAPGNI-FPTEGGFGETVCIFLEVGMGFSMLSVLTTNFKLRRACG 500
            ..:|...|.:.|..::....|....: ...:|.....:...|.:.:.||::||....|:|.:|.|
Mouse   494 GIIFNILVGVGLGCLLQIIRNHVVEVKLEPDGLLVWVLASALGLSLIFSLVSVPLQCFQLSKAYG 558

  Fly   501 FLLVSYYIFFVGVLILLEKGVIH 523
            ..|:.:||.|:.|::|.|.||||
Mouse   559 LCLLLFYICFLVVVLLTEFGVIH 581

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13223	NP_610656.1	Na_Ca_ex	45..194	CDD:279963	48/162 (30%)
CG13223	NP_610656.1	Na_Ca_ex	365..516	CDD:279963	41/151 (27%)
Slc8b1	NP_573484.2	Na_Ca_ex	103..246	CDD:279963	44/149 (30%)
Slc8b1	NP_573484.2	Na_Ca_ex	421..574	CDD:279963	41/152 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837969
Domainoid	1	1.000	68	1.000	Domainoid score	I9715
eggNOG	1	0.900	-	-		E1_COG0530
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4675
OMA	1	1.010	-	-		QHG57812
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000933
OrthoInspector	1	1.000	-	-		otm42568
orthoMCL	1	0.900	-	-		OOG6_101277
Panther	1	1.100	-	-	O	PTHR12266
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1775
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.690