DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment metro and DLG5

DIOPT Version :9

Sequence 1:NP_610642.2 Gene:metro / 36176 FlyBaseID:FBgn0050021 Length:595 Species:Drosophila melanogaster
Sequence 2:NP_004738.3 Gene:DLG5 / 9231 HGNCID:2904 Length:1919 Species:Homo sapiens


Alignment Length:554 Identity:120/554 - (21%)
Similarity:228/554 - (41%) Gaps:102/554 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    80 VLEQLSQHCH-LNDDCKEAFHLLQDSHLQHLLFAHDAIAQKDFYPHLPEAPVEMDEDEETIKIVQ 143
            :|.|.:.|.| |:...:.:.||  |....|...........: :|.:.:..:|.||...|....|
Human  1423 ILAQYNPHVHQLSSHSRSSSHL--DPAGTHSTLQGSGTTTPE-HPSVIDPLMEQDEGPSTPPAKQ 1484

  Fly   144 LVKSNEPLTG---AQSTEPIVGATIKTDEESGKIIIARIMHG----------GAADRSGLIHVGD 195
               |:..:.|   .::.||.|....|:..|.|..:....:||          .|....||: .||
Human  1485 ---SSSRIAGDANKKTLEPRVVFIKKSQLELGVHLCGGNLHGVFVAEVEDDSPAKGPDGLV-PGD 1545

  Fly   196 EVIEVNNINVEGKTPGDV-LTILQNSEGT-ITFKLVPAD---NKGAQRESKVRVRAHFDYNPDVD 255
            .::|..:::|..||..:| :.:|:..:|. :..:..|.:   .||...:| ..:||.:|...|| 
Human  1546 LILEYGSLDVRNKTVEEVYVEMLKPRDGVRLKVQYRP
EEFTKAKGLPGDS-FYIRALYDRLADV- 1608

  Fly   256 PYIPCKEAGLAFQRGDVLHIVAQDDAY-------W--WQARKEHERSARAGLIPSRALQERRILH 311
                  |..|:|::.|:|::   ||..       |  ||. .|:.:..:.|.|||:.:.::....
Human  1609 ------EQELSFKKDDILYV---DDTLPQGTFGSWMAWQL-DENAQKIQRGQIPSKYVMDQEFSR 1663

  Fly   312 DRTQKNGTDLDSKPGSCASLCTTPPGSPRLPASSSTSSCRQPKTKKIM-----YDLTENDDFDRE 371
            ..:.....|.:|             .:..|.|::..|..|:....|..     .||...|.|..:
Human  1664 RLSMSEVKDDNS-------------ATKTLSAAARRSFFRRKHKHKRSGSKDGKDLLALDAFSSD 1715

  Fly   372 QIATYEE-VAKLYPRP-----GVFRPIVLIGAPGVGRNELRRRLIARDPEKF-RSPVPYTTRPMR 429
            .|..:|: |:..|.|.     ...||::::| |.:  :.::..|:...|.|| |.|:        
Human  1716 SIPLFEDSVSLAYQRVQKVDCTALRPVLILG-PLL--DVVKEMLVNEAPGKFCRCPL-------- 1769

  Fly   430 TGEVAGREYIFVAREKMDADIEAGKFVEHGEYKGHLYGTSAESVKSIV--NAGCVCVLSPHYQAI 492
                   |.:..:::.::..::...||::....||...|:..|:|.|.  |..|:..::||  ||
Human  1770 -------EVMKASQQAIERGVKDCLFVDYKRRSGHFDVTTVASIKEITEKNRHCLLDIAPH--AI 1825

  Fly   493 KTLRTAQLKPFLIHVKPPELDILKATRTEARAKSTFDEANARSFTDEEFEDMIKSAERIDFLYGH 557
            :.|....:.|.:|.:.......:|..|.....:....:.:::    |:||    :|::::..|..
Human  1826 ERLHHMHIYPIVIFIHYKSAKHIKEQRDPIYLRDKVTQRHSK----EQFE----AAQKLEQEYSR 1882

  Fly   558 FFDVELVNGELVNAFEQLVQNVQRLENEPVWAPS 591
            :|...:..|.|.:...|::..|.:.:|:.:|.|:
Human  1883 YFTGVIQGGALSSICTQILAMVNQEQNKVLWIPA 1916

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
metroNP_610642.2 L27 17..68 CDD:197794
L27 75..127 CDD:197794 10/47 (21%)
PDZ_signaling 139..229 CDD:238492 23/104 (22%)
SH3_MPP 243..302 CDD:212796 19/67 (28%)
Guanylate_kin 390..575 CDD:279019 38/187 (20%)
GuKc 399..580 CDD:214504 35/183 (19%)
DLG5NP_004738.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 98..142
Takusan 130..212 CDD:282652
TPR_MLP1_2 231..353 CDD:285204
COG1340 295..587 CDD:224259
FliJ 310..449 CDD:304890
BAR 417..601 CDD:299863
PDZ_signaling 620..707 CDD:238492
DegQ <702..771 CDD:223343
PDZ_signaling 722..790 CDD:238492
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 927..1122
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1150..1187
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1201..1230
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1245..1264
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1271..1306
PDZ 1347..1429 CDD:214570 2/5 (40%)
dbPDZ_assoc 1427..1499 CDD:293216 15/77 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1434..1493 13/64 (20%)
PDZ 1499..1582 CDD:214570 20/83 (24%)
SH3_DLG5 1597..1659 CDD:212794 20/72 (28%)
GuKc 1732..1908 CDD:214504 40/203 (20%)
Guanylate_kin 1740..1907 CDD:279019 40/194 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0194
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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